455303-00-1
Chemical Structure
ALizarin complexone dihydrate
- CAS No.: 455303-00-1
- Formula:C19H19NO10
- Molecular Weight:421.35
IUPAC Name: 2,2'-(((3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)azanediyl)diacetic acid dihydrate
InChIKey: LLNGUADXYFYGGJ-UHFFFAOYSA-N
SMILES: O=C(CN(CC(C=C1C2=O)=C(C(O)=C1C(C3=C2C=CC=C3)=O)O)CC(O)=O)O.O.O
Biological Activity: ALizarin complexone dihydrate is the dehydrate of Alizarin complexone (HY-121075). Alizarin complexone is a calcium-binding fluorescent dye. Alizarin complexone stains mineralized areas of bone by binding to calcium crystals. Alizarin complexone inhibits the reverse transcriptase activity of RAV-2, HIV-1, and RSV with IC50 values of 3.8 μg/mL, 45 μg/mL, and 100 μg/mL, respectively. Alizarin complexone exhibits antiviral activity against HIV-1 and RSV. Alizarin complexone delays RSV-induced tumor induction in chickens[1][2][3][4].
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ALizarin complexone dihydrate | ALizarin complexone dihydrate is the dehydrate of Alizarin complexone (HY-121075). Alizarin complexone is a calcium-binding fluorescent dye. Alizarin complexone stains mineralized areas of bone by binding to calcium crystals. Alizarin complexone inhibits the reverse transcriptase activity of RAV-2, HIV-1, and RSV with IC50 values of 3.8 μg/mL, 45 μg/mL, and 100 μg/mL, respectively. Alizarin complexone exhibits antiviral activity against HIV-1 and RSV. Alizarin complexone delays RSV-induced tumor induction in chickens. | |||||||||||||||||||||
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- [1]. Higuchi H, et al. Antiretroviral activities of anthraquinones and their inhibitory effects on reverse transcriptase. Antiviral Res. 1991;15(3):205-216. [Content Brief]
- [2]. Oshima T, et al. Selective extraction of histidine derivatives by metal affinity with a copper(II)-chelating ligand complex in an aqueous two-phase system. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;990:73-79. [Content Brief]
- [3]. Yu T, et al. Live imaging of osteoclast inhibition by bisphosphonates in a medaka osteoporosis model. Dis Model Mech. 2016 Feb;9(2):155-63. [Content Brief]
- [4]. Cui M, et al. New role of calcium-binding fluorescent dye alizarin complexone in detecting permeability from articular cartilage to subchondral bone. FASEB Bioadv. 2024 Oct 7;6(11):539-554. [Content Brief]
Keywords
