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Art. -Nr.: HY-146547

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Anti-inflammatory agent 17

Anti-inflammatory agent 17 is a potent and orally active anti-inflammatory agent. Anti-inflammatory agent 17 inhibits the release of IL-6 and TNF-α in vitro experiments without cytotoxicity. Anti-inflammatory agent 17 exhibits anti-inflammatory activity in vivo. Anti-inflammatory agent 17 has the potential for the research of Acute lung injury (ALI).

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CAS. Nr.: 2763226-84-0
Formel: C₂₀H₂₃NO₅
Molecular Weight:357.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Anti-inflammatory agent 17 Chemical Structure

CAS. Nr.: 2763226-84-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

TNF-α

2.576 μM (IC₅₀)

IL-6

8.254 μM (IC₅₀)

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

Alle TNF Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Anti-inflammatory agent 17 (compound 5b) (10 µM; 24 h) displays no toxicity in J774a.1 cells^[1].
Anti-inflammatory agent 17 (1.25, 2.5, 5, 10 µM; 2 h) inhibits the production of IL-6 (IC₅₀=8.254 µM) and TNF-α (IC₅₀=2.576 µM) in J774a.1 cells in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

J774a.1 cells
Concentration:

10 µM
Incubation Time:

24 h
Result:

Displayed no toxicity in J774a.1 cells.

Immunofluorescence^[1]

Cell Line:

J774A.1 cells
Concentration:

1.25, 2.5, 5, 10 µM
Incubation Time:

2 h
Result:

Inhibited the production of IL-6 (IC₅₀=8.254 µM) and TNF-α (IC₅₀=2.576 µM) in J774a.1 cells in a dose-dependent manner.

In Vivo

Anti-inflammatory agent 17 (20 mg/kg; intragastric administration) exhibits protective effect on LPS (lipopolysaccharide)-induced ALI in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57/BL6 mice^[1]
Dosage:

20 mg/kg
Administration:

Intragastric administration
Result:

Exhibited protective effect on LPS-induced ALI in mice.

Chemical Information

CAS. Nr. 2763226-84-0
Molecular Weight 357.40
Formel C₂₀H₂₃NO₅
SMILES

CN(CCCOC1=CC=C(C(C(/C=C/C2=CC(O)=C(C=C2)O)=O)=C1)O)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang X,et al. Design, synthesis and bioactivity evaluation of fisetin derivatives as potential anti-inflammatory agents against LPS-induced acute lung injury. Bioorg Med Chem. 2021; 49:116456. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
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Anti-inflammatory agent 17

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Alle TNF Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Anti-inflammatory agent 17 Related Classifications

HY-146547 Related Classifications