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Art. -Nr.: HY-183997

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Cbl-b-IN-33

Cbl-b-IN-33 is an orally active, selective inhibitor of Casitas B-lineage lymphoma-b (Cbl-b) with an IC₅₀ of 7 nM and a K_d of 1.2 nM. Cbl-b-IN-33 inhibits non-phosphorylated E3 ubiquitin ligase Cbl-b, induces IL-2 activation in peripheral blood mononuclear cells, and exerts tumor growth inhibitory effects in a mouse colon cancer model. Cbl-b-IN-33 can be used for the research of colon cancer.

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CAS. Nr.: 2815221-18-0
Formel: C₂₉H₃₀F₅N₅O
Molecular Weight:559.57

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cbl-b-IN-33 Chemical Structure

CAS. Nr.: 2815221-18-0

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

IL-2

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vitro

Cbl-b-IN-33 (Compound 16) (24 h) induces IL-2 production in PBMCs with an EC₅₀ of 0.015 μM^[1].
Cbl-b-IN-33 has predicted hepatic clearance values of 14 mL/min/kg in human liver microsomes, 32 mL/min/kg in rat liver microsomes, and 66 mL/min/kg in mouse liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cbl-b-IN-33 (Compound 16) (45-90 mg/kg; p.o.; once-twice daily for 15 days) produces significant tumor growth inhibition of 78% at 45 mg/kg BID and 82% at 90 mg/kg QD in a murine CT26 colon cancer syngeneic model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

syngeneic model strain (CT26 colon cancer implantation)^[1]
Dosage:

45 mg/kg (TGI 78%); 90 mg/kg (TGI 82%)
Administration:

p.o.; twice daily (45 mg/kg); once daily (90 mg/kg) for 15 days
Result:

Achieved 78% tumor growth inhibition.
Achieved 82% tumor growth inhibition.
Showed no significant body weight changes compared to untreated groups.

Chemical Information

CAS. Nr. 2815221-18-0
Molecular Weight 559.57
Formel C₂₉H₃₀F₅N₅O
SMILES

O=C1C2=C(C(C(F)(F)F)=CC(CNC3(C)CCC3)=C2)CN1C4=CC(C5(CC(F)(F)C5)CC6=NN=CN6C)=CC=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Lambrecht MJ, et al. Optimization and In Vivo Characterization of a Series of Cbl-b Inactive-State Inhibitors. ACS Medicinal Chemistry Letters. 2026 May 14.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
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Cbl-b-IN-33

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Cbl-b-IN-33 Related Classifications

HY-183997 Related Classifications