2815221-18-0
Chemical Structure
Cbl-b-IN-33
- CAS No.: 2815221-18-0
- Formula:C29H30F5N5O
- Molecular Weight:559.57
InChIKey: HPIMNXYLWRMVMB-UHFFFAOYSA-N
SMILES: O=C1C2=C(C(C(F)(F)F)=CC(CNC3(C)CCC3)=C2)CN1C4=CC(C5(CC(F)(F)C5)CC6=NN=CN6C)=CC=C4
Biological Activity: Cbl-b-IN-33 is an orally active, selective inhibitor of Casitas B-lineage lymphoma-b (Cbl-b) with an IC50 of 7 nM and a Kd of 1.2 nM. Cbl-b-IN-33 inhibits non-phosphorylated E3 ubiquitin ligase Cbl-b, induces IL-2 activation in peripheral blood mononuclear cells, and exerts tumor growth inhibitory effects in a mouse colon cancer model. Cbl-b-IN-33 can be used for the research of colon cancer[1].
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Cbl-b-IN-33 | Cbl-b-IN-33 is an orally active, selective inhibitor of Casitas B-lineage lymphoma-b (Cbl-b) with an IC50 of 7 nM and a Kd of 1.2 nM. Cbl-b-IN-33 inhibits non-phosphorylated E3 ubiquitin ligase Cbl-b, induces IL-2 activation in peripheral blood mononuclear cells, and exerts tumor growth inhibitory effects in a mouse colon cancer model. Cbl-b-IN-33 can be used for the research of colon cancer. | |||||||||||||||||||||
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Keywords
