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Art. -Nr.: HY-104037A

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Cintirorgon sodium

(Synonyms: LYC-55716 sodium)

9 Cited Publications

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Based on 9 publication(s) in Google Scholar

Cintirorgon sodium is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon sodium (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival.

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CAS. Nr.: 2055538-47-9
Formel: C₂₇H₂₂F₆NNaO₆S
Molecular Weight:625.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Cintirorgon sodium Chemical Structure

CAS. Nr.: 2055538-47-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität

Beschreibung

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Chemical Information

CAS. Nr. 2055538-47-9
Molecular Weight 625.51
Formel C₂₇H₂₂F₆NNaO₆S
SMILES

O=C(O[Na])C(C)(C)C[C@@H]1OC2=CC=C(C3=CC(F)=CC(OC(F)F)=C3)C=C2N(S(=O)(C4=CC=CC(C(F)(F)F)=C4)=O)C1
Synonyms

LYC-55716 sodium
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (9)

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Journal Impact Factor

Pharmacol Res

RORγt agonist synergizes with CTLA-4 antibody to inhibit tumor growth through inhibition of Treg cells via TGF-β signaling in cancer. [Abstract]

2021 Oct:172:105793. PMID: 34339836
Diabetes

Chronic Glucocorticoid Exposure Induced a S1PR2-RORγ Axis to Enhance Hepatic Gluconeogenesis in Male Mice. [Abstract]

2023 Nov 1;72(11):1534-1546. PMID: 37552863
Eur J Med Chem

Discovery of novel N-sulfonamide-tetrahydroisoquinolines as potent retinoic acid receptor-related orphan receptor γt agonists. [Abstract]

2021 Oct 15:222:113585. PMID: 34118722
Antiviral Res

Validation of nuclear receptor RORγ isoform 1 as a novel host-directed antiviral target based on the modulation of cholesterol levels. [Abstract]

2024 Jan:221:105769. PMID: 38056603
bioRxiv

Efficient Generation of Functional TCRαβ+ Cytotoxic T Cells from hiPSCs via Small-Molecule Modulation. [Abstract]

2026 Apr 1:2026.03.31.715684. PMID: 41959015
Patent

US20240325538A1.
Patent

US20240238271A1.
Heliyon

Astragalus regulates the intestinal immune response during sepsis by mediating ILC3 proliferation through RORγt. [Abstract]

2023 Jun 28;9(7):e17766. PMID: 37539221
Patent

US20230226111A1.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lycera Announces Initiation of Phase 1/2a Study ARGON of Immuno-Oncology Candidate LYC-55716 in Patients with Advanced Solid Tumors. Jan 04, 2017.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Cintirorgon sodium

9 Cited Publications

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Chemical Information
Publications (9)
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Cintirorgon sodium

Publications Citing Use of MedChemExpress (MCE) Cintirorgon sodium

Alle ROR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (9)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Cintirorgon sodium Related Classifications

HY-104037A Related Classifications