Art. -Nr.: HY-128851A

Coenzyme A trilithium

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids.

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Reinheit: 98%
CAS. Nr.: 18439-24-2
Formel: C₂₁H₃₃Li₃N₇O₁₆P₃S
Molecular Weight:785.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Coenzyme A trilithium Chemical Structure

CAS. Nr.: 18439-24-2

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (4)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

Coenzyme A functions to generate metabolically active thioesters, while it also has the potential to act as a low-molecular-weight antioxidant in response to oxidative and metabolic stress in exponentially growing bacteria^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 18439-24-2
Appearance Solid
Molecular Weight 785.33
Formel C₂₁H₃₃Li₃N₇O₁₆P₃S
Color White to off-white
SMILES

CC([C@H](C(NCCC(NCCS)=O)=O)O)(C)COP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1OP(O)(O[Li])=O)(O[Li])=O)(O[Li])=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

All WBIHCFlow Cytometry

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Journal Impact Factor

Nature

Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22. [Abstract]

2025 Nov;647(8090):706-715. PMID: 41034585

Coenzyme A trilithium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]

CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. Immunoblots detection for HMGCS2 in small intestinal crypts from control and CoA-treated mice.

Coenzyme A trilithium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]

CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. IHC detection for HMGCS2 in small intestinal crypts from control and CoA-treated mice. Scale bar, 20 µm.

Coenzyme A trilithium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]

Flow cytometry and quantification of IL-22 expression in CD8αβ⁺ cells after 24 h of CoA (500 µM) treatment (n = 8 per group).

Coenzyme A trilithium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715. [Abstract]

CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. IHC for regenerating crypts using OLFM4 as a stem cell marker in control and CoA-treated mice.
J Adv Res

A "DUBTAC" targeting GLUL deubiquitination promotes BMSC osteogenic differentiation and implant osseointegration in type 2 diabetes. [Abstract]

2026 Apr 13:S2090-1232(26)00338-3. PMID: 41980623
J Adv Res

c-Myc-PANK3-EMT axis regulates the structure and function of intestinal barrier in ulcerative colitis. [Abstract]

2025 Dec 8:S2090-1232(25)00996-8. PMID: 41371401

Coenzyme A trilithium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8. [Abstract]

phosphorylation level of PI3K, AKT and ERK in HT29 cells treated with TNF-α/IFN-γ combined with 250 µM CoA.
Med Gas Res

Glycolysis-dependent reactive oxygen species mediate desmopressin acetate-induced rescue of platelet dysfunction caused by antiplatelet therapy. [Abstract]

2026 Mar 26. PMID: 41888039

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 125 mg/mL (159.17 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.2734 mL

6.3668 mL

12.7335 mL

5 mM

0.2547 mL

1.2734 mL

2.5467 mL

10 mM

0.1273 mL

0.6367 mL

1.2734 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Roberta Leonardi, et al. Coenzyme A: back in action. Prog Lipid Res. 2005 Mar-May;44(2-3):125-53. [Content Brief]

[2]. Tsuchiya Y, et al. Protein CoAlation and antioxidant function of coenzyme A in prokaryotic cells. Biochem J. 2018 Jun 6;475(11):1909-1937. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.2734 mL	6.3668 mL	12.7335 mL	31.8338 mL
	5 mM	0.2547 mL	1.2734 mL	2.5467 mL	6.3668 mL
	10 mM	0.1273 mL	0.6367 mL	1.2734 mL	3.1834 mL
	15 mM	0.0849 mL	0.4245 mL	0.8489 mL	2.1223 mL
	20 mM	0.0637 mL	0.3183 mL	0.6367 mL	1.5917 mL
	25 mM	0.0509 mL	0.2547 mL	0.5093 mL	1.2734 mL
	30 mM	0.0424 mL	0.2122 mL	0.4245 mL	1.0611 mL
	40 mM	0.0318 mL	0.1592 mL	0.3183 mL	0.7958 mL
	50 mM	0.0255 mL	0.1273 mL	0.2547 mL	0.6367 mL
	60 mM	0.0212 mL	0.1061 mL	0.2122 mL	0.5306 mL
	80 mM	0.0159 mL	0.0796 mL	0.1592 mL	0.3979 mL
	100 mM	0.0127 mL	0.0637 mL	0.1273 mL	0.3183 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Coenzyme A trilithium

4 Cited Publications

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Coenzyme A trilithium

Publications Citing Use of MedChemExpress (MCE) Coenzyme A trilithium

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Coenzyme A trilithium Related Classifications

HY-128851A Related Classifications