COX-2-IN-10
COX-2-IN-10 is a potent COX-2 inhibitor. COX-2-IN-10 inhibits the production of PGE2 in concentration dependent manner (IC50=2.54 µM). COX-2-IN-10 inhibits the expression of iNOS and COX-2 on mRNA and protein level . COX-2-IN-10 inhibits the production of IL-6, TNF-α and IL-1β.
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- Formel: C31H32FN5O2S
- Molecular Weight:557.68
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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COX-2 |
COX-2-IN-10 (compound 9k) (10 µM, 24 h) exhibits high safety and did not show any significant cytotoxicity over LPS-Induced RAW264.7 macrophage cells[1].
COX-2-IN-10 (0.4, 2, 10 µM) inhibits the production of PGE2 in concentration dependent manner in RAW264.7 macrophage cells (IC50=2.54 µM)[1].
COX-2-IN-10 (2.5, 5, 10 μM) significantly inhibits the mRNA expression of iNOS and COX-2 at 10 μM[1].
COX-2-IN-10 (2.5, 5, 10 μM) significantly inhibits iNOS and COX-2 protein level starting from 10 μM concentration[1].
COX-2-IN-10 (2.5, 5, 10 μM; 1 h) inhibits the production of IL-6, TNF-α and IL-1β[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 macrophage cells
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Concentration:10 µM
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Incubation Time:24 h
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Result:Exhibited high safety and did not show any significant cytotoxicity over LPS-Induced RAW264.7 macrophage cells.
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Cell Line:RAW264.7 macrophage cells
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Concentration:2.5, 5, 10 μM
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Incubation Time:
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Result:Inhibits the mRNA expression of iNOS and COX-2 at 10 μM.
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Cell Line:RAW264.7 macrophage cells
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Concentration:2.5, 5, 10 μM
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Incubation Time:
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Result:Significantly inhibited iNOS and COX-2 protein level starting from 10 μM concentration.
Chemical Information
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Molecular Weight 557.68
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Formel C31H32FN5O2S
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SMILES
CC(C)(N1C=C(C(C2=CC(F)=CC=C2)=N1)C3=CC=NC(NCCCNS(=O)(C4=CC5=C(C=C4)C=CC=C5)=O)=C3)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
COX-2-IN-10 Related Classifications
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