CRTh2 antagonist 4
CRTh2 antagonist 4 (compound 58) is an inhibitor (IC50: 212 nM) of TH2 lymphocyte (CRTH2 or DP2) receptor with high binding affinity (Ki= 37 nM). CRTh2 antagonist 4 can be used in the study of severe allergic diseases.
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- CAS. Nr.: 916046-55-4
- Formel: C20H14ClFN2O5
- Molecular Weight:416.79
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
212 nM
Compound: 58
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Antagonist activity at human CRTH2 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assay
Antagonist activity at human CRTH2 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assay
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[PMID: 18318469] |
Chemical Information
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CAS. Nr. 916046-55-4
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Molecular Weight 416.79
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Formel C20H14ClFN2O5
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SMILES
O=C(O)CN1C(C2(C(N(CC3=CC=CC=C3F)C(C2)=O)=O)C4=C1C=CC(Cl)=C4)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CRTh2 antagonist 4 Related Classifications
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