Erythromycin propionate
Based on 1 publication(s) in Google Scholar
Erythromycin propionate, erythromycin (HY-B0220) derivative, is a macrolide antibiotic used in the treatment of a wide variety of bacterial infections. Erythromycin propionate causes several cases of liver injury which mostly include cholestatic hepatitis. Erythromycin propionate toxicity is related to its inhibitory effect on bile acid transport.
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- CAS. Nr.: 134-36-1
- Formel: C40H71NO14
- Molecular Weight:789.99
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Erythromycin propionate
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Biologische Aktivität
Erythromycin propionate inactivates viral particles by destroying the integrity of the viral membrane, resulting in the release of viral genomic RNA, and the irreversible loss of infection ability. Erythromycin propionate inhibits various flaviviruses, including Zika virus (ZIKV), dengue virus (DENV), yellow fever virus (YFV) and human coronavirus OC43 (HCoV-OC43)[2].
Erythromycin propionate (2.5-10 µM, 48 h) reduces the virus titer of HCoV-OC43 with an IC50 of 1.40 µM, reduces the number of HCoV-OC43 infected BHK-21 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BHK-21
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Concentration:2.5-10 µM
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Incubation Time:48 h
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Result:Reduced the viral nucleoprotein.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats models[1]
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Dosage:450-1200 mg/kg
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Administration:po, once daily for 7 days
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Result:Caused hydropic degeneration of hepatocytes.
Increased serum bilirubin (TBILI) levels and alanine aminotransferase (ALT) activity.
Decreased serum triglyceride (TG) levels and glutathione (GSH) content in liver tissue.
Chemical Information
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CAS. Nr. 134-36-1
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Molecular Weight 789.99
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Formel C40H71NO14
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SMILES
CCC(O[C@H]([C@H](C[C@H](O1)C)N(C)C)[C@@H]1O[C@@H]2[C@H]([C@@H]([C@H](C(O[C@@H]([C@@](O)([C@@H]([C@H](C([C@@H](C[C@]2(O)C)C)=O)C)O)C)CC)=O)C)O[C@H]3C[C@](C)([C@H]([C@@H](O3)C)O)OC)C)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Viruses
Erythromycin Estolate Inhibits Zika Virus Infection by Blocking Viral Entry as a Viral Inactivator. [Abstract]2019 Nov 15;11(11):1064. PMID: 31731598
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