DKK3 - dickkopf WNT signaling pathway inhibitor 3 Gene

Also Known as RIG; CRRL; REIC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27122

About DKK3

Cytogenetic location: 11p15.3 Genomic coordinates (GRCh38): 11:11,963,036-12,009,745 (from NCBI)

This gene has 17 transcripts (splice variants) and 266 orthologues. Biased expression in heart (RPKM 451.8), brain (RPKM 155.8) and 7 other tissues.

Summary

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of Cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

DKK3 Products (4)

mRNA	Protein	Name
NM_001018057.2	NP_001018067.1	dickkopf-related protein 3 isoform 1 precursor
NM_001330220.3	NP_001317149.1	dickkopf-related protein 3 isoform 2 precursor
NM_013253.5	NP_037385.2	dickkopf-related protein 3 isoform 1 precursor
NM_015881.6	NP_056965.3	dickkopf-related protein 3 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in adrenal gland development	IEP IEP: Inferred from expression pattern	12844346	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16981135	GOA
involved in negative regulation of aldosterone biosynthetic process	IDA IDA: Inferred from direct assay	16981135	GOA
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	12857724	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	23538390	GOA
involved in negative regulation of cortisol biosynthetic process	IDA IDA: Inferred from direct assay	16981135	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DKK3 Protein Structure

Dickkopf_N

0
100
200
300
350 a.a.

Protein Preferred Names	Protein Names
dickkopf-related protein 3	RIG-like 5-6

Recombinant DKK3 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P7812	DKK-3 Protein, Human (HEK293, His)	AAF02676.1 (A22-I350)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77640	DKK-3 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9UBP4 (P23-I350)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78681	DKK-3 Protein, Human (R335G, HEK293, His)	Q9UBP4 (A22-I350, R335G)	≥ 95%, as determined by reducing SDS-PAGE.

DKK3 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82106	DKK3 Antibody (YA1851)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P84857	DKK3 Antibody (YA4554)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
HY-P84857A	DKK3 Antibody (YA4554)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
HY-P85123	DKK3 Antibody (YA4815)	WB, FC, ELISA	Human, Monkey

Related Diseases

Diseases	Alias
Polycystic Liver Disease	Autosomal Dominant Polycystic Liver Disease Isolated Polycystic Liver Disease Pcld Congenital Cystic Liver Disease Congenital Hepatic Cyst Fibrocystic Liver Disease Isolated Autosomal Dominant Polycystic Liver Disease Adpcld Liver Disease, Polycystic Multiple Cysts Of Liver Pld - [Polycystic Liver Disease] Polycystic Liver Disorder Polycystic Liver Congenital Polycystic Disease Of Liver Congenital Polycystic Liver Disease
Ventricular Tachycardia, Catecholaminergic Polymorphic, 4	Catecholaminergic Polymorphic Ventricular Tachycardia 4 CPVT4 Bidirectional Tachycardia Stress-Induced Polymorphic Ventricular Tachycardia Cvpt4 Double Tachycardia Induced By Catecholamines Malignant Paroxysmal Ventricular Tachycardia Multifocal Ventricular Premature Beats Paroxysmal Ventricular Fibrillation Syncopal Paroxysmal Tachycardia Syncopal Tachyarythmia Vtsip Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 4 Multifocal Pvcs Multifocal Premature Ventricular Beats Paroxysmal Familial Ventricular Fibrillation Ventricular Tachycardia, Catecholaminergic Polymorphic, 1
Witkop Syndrome	Tooth And Nail Syndrome Hypoplastic Enamel-Onycholysis-Hypohidrosis Syndrome Tns Ectodermal Dysplasia 3, Witkop Type ECTD3 Ectodermal Dysplasia 3, Tooth/Nail Type Tooth-And-Nail Syndrome Dysplasia Of Nails With Hypodontia Nail Dysplasia With Hypodontia Witkop'S Syndrome Hypodontia - Dysplasia Of Nails Hypodontia-Dysplasia Of Nails Syndrome Hypodontia-Nail Dysgenesis Syndrome Hypodontia-Nail Dysgenesis
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Ventricular Tachycardia, Catecholaminergic Polymorphic, 3	Catecholaminergic Polymorphic Ventricular Tachycardia 3 CPVT3 Cvpt3 Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 3
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-W107409	Meridianin C		99.68%	Unkown
HY-179459	SJ-300	Inhibitor	/	Unkown
HY-RS03789	DKK3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16965	Dkk3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23408	Dkk3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P990250	Anti-Mouse DKK3 Antibody (DKK3-4.22)		95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DKK3	VGNC	VGNC:71804
Bos taurus	DKK3	VGNC	VGNC:28081
Felis catus	DKK3	VGNC	VGNC:61506
Canis familiaris	DKK3	VGNC	VGNC:39971
Rattus norvegicus	DKK3	RGD	RGD:621846
Mus musculus	DKK3	MGD	MGI:1354952
Others	DKK3	NCBI