DKK3 Antibody (YA4815)
(Synonyms: DKK3; REIC; Dickkopf-related protein 3; Dickkopf-3; Dkk-3; hDkk-3)DKK3 Antibody (YA4815) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to DKK3.
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Host:
Mouse
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Application:
WB, FC, ELISA
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Reactivity :
Human, Monkey
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:400 | 1:10000 |
Product Details
DKK3 Antibody (YA4815) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to DKK3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Monkey
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Calculated Molecular Weight Predicted band size: 38 kDa;
Purified recombinant fragment of human Dkk-3 expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DKK3 is an Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease
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Subcellular Localization
Secreted
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Expression
Tissue_specificity:It is expressed at the highest levels in the heart, brain, and spinal cord. -
Subunit
Interacts with LRP5 and LRP6
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SwissProt ID
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Synonyms
DKK3; REIC; Dickkopf-related protein 3; Dickkopf-3; Dkk-3; hDkk-3
Documentation
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