Anti-Mouse DKK3 Antibody (DKK3-4.22) 

Anti-Mouse DKK3 Antibody (DKK3-4.22) is an anti-mouse DKK3 IgG1 monoclonal antibody. Anti-Mouse DKK3 Antibody (DKK3-4.22) can improve kidney function and increases T cell infiltration. Anti-Mouse DKK3 Antibody (DKK3-4.22) can reduce skin inflammation by blocking the immunosuppressive function of DKK3. Anti-Mouse DKK3 Antibody (DKK3-4.22) can be used for researches on inflammation conditions such as unilateral ureteral obstruction (UUO) and experimental autoimmune encephalomyelitis (EAE)^[1][2].

Mouse IgG1 kappa

Mouse IgG1 kappa, Isotype Control

Mouse

DKK3

Anti-Mouse DKK3 Antibody (DKK3-4.22) (0.5-1 mg, i.p., once every 3 days, for 21 days) improves renal function and increases T cell infiltration in male C57BL/6 mice with an unilateral ureteral obstruction (UUO) model^[1].
Anti-Mouse DKK3 Antibody (DKK3-4.22) (500 μg, i.p., once weekly, for 3 times) can block the immunosuppressive function of DKK3 in transgenic Ker-MBP mice with an experimental autoimmune encephalomyelitis (EAE) model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

50781  [NCBI]

Q9QUN9

in vivo DKK3 blocking; in vitro DKK3 blocking; Western blot; Flow cytometry

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Mouse DKK3 Antibody (DKK3-4.22)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Federico G, et al. Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis. JCI Insight. 2016 Jan 21;1(1):e84916.  [Content Brief]

  [2]. Meister M, et al. Self-Antigen Presentation by Keratinocytes in the Inflamed Adult Skin Modulates T-Cell Auto-Reactivity. J Invest Dermatol. 2015 Aug;135(8):1996-2004.  [Content Brief]