DKK3 Antibody (YA4554)(PBS only)
(Synonyms: RIG; REIC)DKK3 Antibody (YA4554) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DKK3.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, FC, ELISA
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Reactivity :
Human, Mouse, Rat, Rabbit, Monkey
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
DKK3 Antibody (YA4554) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DKK3.
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Host Mouse
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Species ReactivityHuman, Mouse, Rat, Rabbit, Monkey
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Observed Molecular WeightObserved band size: 38 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 38 kDa
Purified recombinant fragment of human DKK3 (AA: 91-350 ) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DKK3 is an Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease
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Subcellular Localization
Secreted
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Expression
Tissue_specificity:It is expressed at the highest levels in the heart, brain, and spinal cord. -
Subunit
Interacts with LRP5 and LRP6
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SwissProt ID
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Synonyms
RIG; REIC
Documentation
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