DKK-3 Protein, Human (Biotinylated, HEK293, His-Avi)

DKK-3 protein antagonizes canonical Wnt signaling by blocking LRP5/6-Wnt interactions and forming a ternary complex with KREMEN, thereby promoting LRP5/6 internalization. In vertebrate development, DKK-3, together with other DKKs, critically inhibits Wnt-regulated processes such as axial patterning, limb development, somitogenesis, and eye formation. DKK-3 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived DKK-3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of DKK-3 Protein, Human (Biotinylated, HEK293, His-Avi) is 328 a.a., with molecular weight of 50-70 kDa.

The DKK-3 protein functions as an antagonist of canonical Wnt signaling by impeding the interaction between LRP5/6 and Wnt and forming a ternary complex with the transmembrane protein KREMEN, facilitating the internalization of LRP5/6. Within vertebrate development, DKKs, including DKK-3, play a crucial role by locally inhibiting Wnt-regulated processes such as antero-posterior axial patterning, limb development, somitogenesis, and eye formation. In the adult, DKKs are implicated in diverse physiological and pathological conditions, encompassing bone formation, bone disease, cancer, and Alzheimer's disease (By similarity). Notably, DKK-3's interaction with LRP5 and LRP6 highlights its regulatory involvement in inhibiting Wnt signaling and its potential impact on various cellular processes.

Human

HEK293

C-Avi;C-His

Q9UBP4 (P23-I350)

27122  [NCBI]

50-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.