Sirt5 - sirtuin 5 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 306840

About Sirt5

Primary_assembly 17: 21,310,028-21,337,101 reverse strand.mRatBN7.2:CM026990.1

This gene has 1 transcript (splice variant), 265 orthologues and 6 paralogues. Biased expression in Heart (RPKM 365.5), Brain (RPKM 277.9) and 9 other tissues.

Summary

Predicted to enable NAD+ binding activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; and zinc ion binding activity. Involved in negative regulation of cardiac muscle cell apoptotic process and response to nutrient levels. Predicted to be located in mitochondrial inner membrane; mitochondrial intermembrane space; and mitochondrial matrix. Predicted to be active in cytosol and mitochondrion. Orthologous to human SIRT5 (Sirtuin 5). [provided by Alliance of Genome Resources, Apr 2022]

Sirt5 Products (1)

mRNA Protein Name
NM_001004256.1 NP_001004256.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
24192575 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
21826711 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sirt5 Protein Structure

SIRT5_Af1_CobB

SIRT5_Af1_CobB: cd01412 (50 - 300)

  • 0
  • 100
  • 200
  • 310 a.a.
Protein Preferred Names Protein Names

NAD-dependent protein deacylase sirtuin-5, mitochondrial

  • NAD-dependent deacetylase sirtuin-5

  • NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial

  • SIR2-like protein 5

  • regulatory protein SIR2 homolog 5

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-B0879A Suramin sodium salt Inhibitor 99.98% Yes
HY-B0879 Suramin Inhibitor / Unkown

Pre-clinical Phase

Bioactive Molecules (7)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-145651 Et-29 Inhibitor 99.89% Unkown
HY-146387 SIRT5 inhibitor 3 Inhibitor 98.0% Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor 98.37% Unkown
HY-168681 Sirtuin-IN-2 Inhibitor / Unkown
HY-152214 SIRT5 inhibitor 5 Inhibitor / Unkown
HY-184000 SIRT5-IN-10 Inhibitor / Unkown
HY-146386 SIRT5 inhibitor 2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt5 NCBI NCBI:23408