SIRT5 inhibitor 3
Based on 1 Customer Validation
SIRT5 inhibitor 3 (compound 46) is a potent and competitive SIRT5 inhibitor with an IC50 value of 5.9 μM. SIRT5 inhibitor 3 can inhibit SIRT5 desuccinylation. SIRT5 inhibitor 3 can be used for researching cancer and neurodegenerative diseases.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 2128651-12-5
- Formula: C22H12FN3O4
- Molecular Weight:401.35
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
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SIRT5 5.9 μM (IC50) |
Chemical Information
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CAS No. 2128651-12-5
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Appearance Solid
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Molecular Weight 401.35
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Formula C22H12FN3O4
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Color Orange to red
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SMILES
N#CC1=CC=C(C=C1F)NC(/C(C#N)=C/C2=CC=C(O2)C3=CC=C(C=C3)C(O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (62.29 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4916 mL | 12.4580 mL | 24.9159 mL | 62.2898 mL |
| 5 mM | 0.4983 mL | 2.4916 mL | 4.9832 mL | 12.4580 mL | |
| 10 mM | 0.2492 mL | 1.2458 mL | 2.4916 mL | 6.2290 mL | |
| 15 mM | 0.1661 mL | 0.8305 mL | 1.6611 mL | 4.1527 mL | |
| 20 mM | 0.1246 mL | 0.6229 mL | 1.2458 mL | 3.1145 mL | |
| 25 mM | 0.0997 mL | 0.4983 mL | 0.9966 mL | 2.4916 mL | |
| 30 mM | 0.0831 mL | 0.4153 mL | 0.8305 mL | 2.0763 mL | |
| 40 mM | 0.0623 mL | 0.3114 mL | 0.6229 mL | 1.5572 mL | |
| 50 mM | 0.0498 mL | 0.2492 mL | 0.4983 mL | 1.2458 mL | |
| 60 mM | 0.0415 mL | 0.2076 mL | 0.4153 mL | 1.0382 mL |