SIRT5 inhibitor 3

Cat. No.: HY-146387: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

SIRT5 inhibitor 3 (compound 46) is a potent and competitive SIRT5 inhibitor with an IC₅₀ value of 5.9 μM. SIRT5 inhibitor 3 can inhibit SIRT5 desuccinylation. SIRT5 inhibitor 3 can be used for researching cancer and neurodegenerative diseases.

For research use only. We do not sell to patients.

SIRT5 inhibitor 3 Chemical Structure

CAS No. : 2128651-12-5

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 590	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

SIRT5

5.9 μM (IC₅₀)

Molecular Weight

401.35

Formula

C₂₂H₁₂FN₃O₄

CAS No.

2128651-12-5

Appearance

Solid

Color

Orange to red

SMILES

N#CC1=CC=C(C=C1F)NC(/C(C#N)=C/C2=CC=C(O2)C3=CC=C(C=C3)C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (62.29 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4916 mL	12.4580 mL	24.9159 mL
5 mM	0.4983 mL	2.4916 mL	4.9832 mL
10 mM	0.2492 mL	1.2458 mL	2.4916 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Wang Y, et al. Overview of SIRT5 as a potential therapeutic target: Structure, function and inhibitors. Eur J Med Chem. 2022;236:114363. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4916 mL	12.4580 mL	24.9159 mL	62.2898 mL
	5 mM	0.4983 mL	2.4916 mL	4.9832 mL	12.4580 mL
	10 mM	0.2492 mL	1.2458 mL	2.4916 mL	6.2290 mL
	15 mM	0.1661 mL	0.8305 mL	1.6611 mL	4.1527 mL
	20 mM	0.1246 mL	0.6229 mL	1.2458 mL	3.1145 mL
	25 mM	0.0997 mL	0.4983 mL	0.9966 mL	2.4916 mL
	30 mM	0.0831 mL	0.4153 mL	0.8305 mL	2.0763 mL
	40 mM	0.0623 mL	0.3114 mL	0.6229 mL	1.5572 mL
	50 mM	0.0498 mL	0.2492 mL	0.4983 mL	1.2458 mL
	60 mM	0.0415 mL	0.2076 mL	0.4153 mL	1.0382 mL