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Cat. No.: HY-168681

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Sirtuin-IN-2

Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, which is a key target for leukemia and breast cancer.

For research use only. We do not sell to patients.

Formula: C₂₈H₄₆N₈O₆S
Molecular Weight:622.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Sirtuin-IN-2 Chemical Structure

Size

Price

Stock

Quantity

Sample (0.1mg)

In-stock

(In Japan)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, which is a key target for leukemia and breast cancer^[1].

IC₅₀ & Target

SIRT5

All Sirtuin Isoforms :

Chemical Information

Molecular Weight 622.78
Formula C₂₈H₄₆N₈O₆S
SMILES

S=C(NCCC(O)=O)NCCCC[C@H](NC(OCC1=CC=CC=C1)=O)C(N[C@@H](CCCNC(N)=N)C(NCCCC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hansen TN, et al. Mechanism-based inactivators of sirtuin 5: A focused structure-activity relationship study. Bioorg Med Chem Lett. 2025 Jan 1;115:130017. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

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Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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