Art. -Nr.: HY-N9484

Menthofuran, 84%

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Menthofuran, 84% is an orally active modulator of pulegone reductase with gastroprotective activity, and it is the metabolite of (R)-(+)-Pulegone. Menthofuran, 84% reduces the transcriptional level of pulegone reductase in immature peppermint leaves, increases the content of pulegone in peppermint essential oil, and regulates the biosynthesis of peppermint essential oil through a feedforward-like inhibition mechanism. Menthofuran, 84% decreases total gastric acidity, restores non-protein thiol levels, inhibits lipid peroxidation, and reduces myeloperoxidase activity, with its mechanism of action related to the NOS pathway and endogenous prostaglandins. Menthofuran, 84% can be used in studies related to gastric ulcers.

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Reinheit: 84.25%
CAS. Nr.: 494-90-6
Formel: C₁₀H₁₄O
Molecular Weight:150.22

Speicherung:

Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Menthofuran, 84% Chemical Structure

CAS. Nr.: 494-90-6

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Menthofuran 84% does not inhibit the activity of partially purified pulegone reductase from mint leaves in vitro^[1].
Menthofuran 84% significantly downregulates the transcript level of menthone reductase in immature peppermint leaves^[1].
Menthofuran 84% is produced via an NADPH- and oxygen-dependent conversion reaction of (-)-pulegone by soluble microsomal proteins derived from glandular trichome secretory cells of Mentha pulegium^[2].
Menthofuran 84% can be produced via the biotransformation of (-)-pulegone in Saccharomyces cerevisiae strains WAT11U and WAT21U^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Menthofuran, 84% (12.5-100 mg/kg; p.o.; single administration) exerts dose-dependent gastroprotective activity against ethanol-induced gastric ulcers in male Wistar rats^[3].
Menthofuran, 84% (12.5-100 mg/kg; p.o.; 3.5 h interval between two administrations) significantly reduces the ulcer index of Indomethacin (HY-14397)-induced gastric ulcers in male Wistar rats^[3].
Menthofuran, 84% (50-100 mg/kg; p.o.; single administration) inhibits ischemia-reperfusion-induced gastric ulcer formation in male Wistar rats^[3].
Menthofuran, 84% (50-100 mg/kg; intradermal injection; single administration) exhibits antisecretory activity in pylorus-ligated male Wistar rats at the dose of 50 mg/kg, increases gastric juice pH and reduces total acidity without altering gastric juice volume^[3].
Menthofuran, 84% (50-100 mg/kg; intradermal injection; single administration) reduces gastric wall mucus content in pylorus-ligated male Wistar rats^[3].
Menthofuran, 84% (50 mg/kg; p.o.; single administration) modulates antioxidant and anti-inflammatory biomarkers in an ethanol-induced gastric ulcer model of male Wistar rats, restores NPSH levels, and reduces MDA levels and MPO activity^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats (male, 70-90 days old, 250-300 g)^[3]
Dosage:

12.5 mg/kg; 25 mg/kg; 50 mg/kg; 100 mg/kg
Administration:

p.o.; single dose
Result:

Reduced ulcerated area percentage.
Failed to reduce ulcer area at 12.5 mg/kg (22.44%).

Animal Model:

Wistar rats (male, 70-90 days old, 250-300 g)^[3]
Dosage:

12.5 mg/kg; 25 mg/kg; 50 mg/kg; 100 mg/kg
Administration:

p.o.; two doses 3.5 h apart
Result:

Reduced ulcer index.

Animal Model:

Wistar rats (male, 70-90 days old, 250-300 g)^[3]
Dosage:

50 mg/kg; 100 mg/kg
Administration:

p.o.; single dose
Result:

Reduced ulcerated area percentage.

Animal Model:

Wistar rats (male, 70-90 days old, 250-300 g)^[3]
Dosage:

50 mg/kg; 100 mg/kg
Administration:

i.d.; single dose
Result:

Elevated gastric juice pH to 5.62 at 50 mg/kg, with unaltered pH (3.42) at 100 mg/kg.
Lowered total gastric juice acidity to 6.98 μEq/h at 50 mg/kg, with unaffected acidity (17.68 μEq/h) at 100 mg/kg.
Retained unchanged gastric juice volume at both doses (50 mg/kg: 2.6 mL; 100 mg/kg: 3.0 mL; vehicle: 2.9 mL).

Animal Model:

Wistar rats (male, 70-90 days old, 250-300 g)^[3]
Dosage:

50 mg/kg; 100 mg/kg
Administration:

i.d.; single dose
Result:

Reduced gastric wall mucus.
Unchanged gastric wall catalase at both doses.

Animal Model:

Wistar rats (male, 70-90 days old, 250-300 g)^[3]
Dosage:

50 mg/kg
Administration:

p.o.; single dose
Result:

Restored gastric wall NPSH levels to 190.62 μg/g vs vehicle 113.05 μg/g, control 253.06 μg/g.
Reduced gastric wall MDA levels to 71.70 nmol/g vs vehicle 89.49 nmol/g, control 69.35 nmol/g.
Reduced gastric wall MPO activity to 5.62 U/mg vs vehicle 10.47 U/mg, control 3.19 U/mg.

Chemical Information

CAS. Nr. 494-90-6
Appearance Liquid (Density: 0.97 g/cm³)
Molecular Weight 150.22
Formel C₁₀H₁₄O
Color Colorless to light yellow
SMILES

CC(C1)CCC2=C1OC=C2C
Structure Classification
- Others
Initial Source
- Plants
- Labiatae
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (665.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.6569 mL

33.2845 mL

66.5690 mL

5 mM

1.3314 mL

6.6569 mL

13.3138 mL

10 mM

0.6657 mL

3.3285 mL

6.6569 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (16.64 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (16.64 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (16.64 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
SDS (761 KB)
- English - EN (761 KB)
- Français - FR (761 KB)
- Deutsch - DE (761 KB)
- Norwegian - NO (761 KB)
- Español - ES (761 KB)
- Swedish - SV (761 KB)
- Italian - IT (761 KB)
- Korean - KR (761 KB)
- Portuguese - PT (761 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mahmoud SS, et al. Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase. Proceedings of the National Academy of Sciences of the United States of America. 2003 Nov 25;100(24):14481-6. [Content Brief]

[2]. Bertea CM, et al. Demonstration That Menthofuran Synthase of Mint (Mentha) Is a Cytochrome P450 Monooxygenase: Cloning, Functional Expression, and Characterization of the Responsible Gene. Archives of Biochemistry and Biophysics. 2001 Jun 15;390(2):279-286.

[3]. Alves NM, et al. Antioxidant Mechanisms Underlying the Gastroprotective Effect of Menthofuran on Experimentally Induced Gastric Lesions in Rodents. Evidence-based complementary and alternative medicine : eCAM. 2023;2023:9192494. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.6569 mL	33.2845 mL	66.5690 mL	166.4226 mL
	5 mM	1.3314 mL	6.6569 mL	13.3138 mL	33.2845 mL
	10 mM	0.6657 mL	3.3285 mL	6.6569 mL	16.6423 mL
	15 mM	0.4438 mL	2.2190 mL	4.4379 mL	11.0948 mL
	20 mM	0.3328 mL	1.6642 mL	3.3285 mL	8.3211 mL
	25 mM	0.2663 mL	1.3314 mL	2.6628 mL	6.6569 mL
	30 mM	0.2219 mL	1.1095 mL	2.2190 mL	5.5474 mL
	40 mM	0.1664 mL	0.8321 mL	1.6642 mL	4.1606 mL
	50 mM	0.1331 mL	0.6657 mL	1.3314 mL	3.3285 mL
	60 mM	0.1109 mL	0.5547 mL	1.1095 mL	2.7737 mL
	80 mM	0.0832 mL	0.4161 mL	0.8321 mL	2.0803 mL
	100 mM	0.0666 mL	0.3328 mL	0.6657 mL	1.6642 mL

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Menthofuran, 84%

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Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Menthofuran, 84%

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Natural Product Library

Ferroptosis Compound Library

Medicine Food Homology Compound Library

Orally Active Compound Library

Traditional Chinese Medicine Active Compound Library

Food Additive Library

Drug Metabolite Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

Tibetan Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

RO5 Drug-like Natural Product Library

Flavor Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Metabolite Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Flavors and Fragrances Compound Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Menthofuran, 84% Related Classifications

HY-N9484 Related Classifications