Art. -Nr.: HY-B0144B

Pitavastatin sodium

(Synonyms: NK-104 sodium)

6 Cited Publications

Kundenbewertung

Based on 6 publication(s) in Google Scholar

Pitavastatin (NK-104) sodium is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin sodium inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin sodium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin sodium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects.

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CAS. Nr.: 574705-92-3
Formel: C₂₅H₂₃FNNaO₄
Molecular Weight:443.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

Pitavastatin sodium Chemical Structure

CAS. Nr.: 574705-92-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (6)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

HMG-CoA Reductase^[1]

In Vitro

Pitavastatin inhibits the growth of a panel of ovarian cancer cells, including those considered most likely to represent HGSOC, grown as a monolayers (IC₅₀=0.4-5 μM) or as spheroids (IC₅₀ = 0.6-4 μM)^[4].
Pitavastatin (1 μM; 48 hours) induces apoptosis, evidenced by the increased activity of executioner caspases-3,7 as well as caspase-8 and caspase-9 in Ovcar-8 cells and Ovcar-3 cells^[4].
Pitavastatin (1 μM, 48 hours) causes PARP cleavage in Ovcar-8 cells^[4].
Pitavastatin (0.1 and 1 μM; 1 h, then cells incubate with TNF-α for 6 h) increases the expression of ICAM-1 mRNA through suppressing NF-κB pathway in TNF-α-stimulated human saphenous vein endothelial cells^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[4]

Cell Line:

Ovcar-8 cells
Concentration:

1 μM
Incubation Time:

48 hours
Result:

Induced PARP cleavage.

In Vivo

Pitavastatin (59 mg/kg; p.o.; twice daily for 28 days) causes significant tumour regression^[4].
Pitavastatin (0.1 mg/kg; p.o; daily for 12 weeks) retards the progression of atherosclerosis formation and improves NO bioavailability by eNOS up-regulation and decrease of O^2- in diet induced severe hyperlipidemia rabbit model^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

4 week old female NCR Nu/Nu female mice (bearing Ovcar-4 tumours)^[4]
Dosage:

59 mg/kg
Administration:

p.o.; twice daily for 28 days
Result:

Caused significant tumour regression.

Animal Model:

Female New Zealand white rabbits (diet induced severe hyperlipidemia)^[7]
Dosage:

0.1 mg/kg
Administration:

p.o; daily for 12 weeks
Result:

Retarded the progression of atherosclerosis formation and improved NO bioavailability by eNOS up-regulation and decrease of O^2-.

Chemical Information

CAS. Nr. 574705-92-3
Molecular Weight 443.44
Formel C₂₅H₂₃FNNaO₄
SMILES

O=C(O[Na])C[C@H](O)C[C@H](O)/C=C/C1=C(C2=CC=C(C=C2)F)C3=C(C=CC=C3)N=C1C4CC4
Synonyms

NK-104 sodium
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (6)

All Microbiological AssayIn Vivo Efficacy Study

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Journal Impact Factor

Cancer Res

TRAPPC4 Promotes GPX4 Stability to Drive Ferroptosis Resistance and Tumor Progression in Head and Neck Squamous Cell Carcinoma. [Abstract]

2026 Jul 15;86(14):3436-3458. PMID: 41974002
Antioxidants (Basel)

Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species. [Abstract]

2024 May 29;13(6):667. PMID: 38929106

Pitavastatin sodium purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2024 May 29;13(6):667. [Abstract]

Pitavastatin Calcium (0.5-1 μM) makes FLC fungicidal.

Pitavastatin sodium purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2024 May 29;13(6):667. [Abstract]

PIT (0-25 μM) confers fungicidal properties to voriconazole, ketoconazole, itraconazole, and miconazole.

Pitavastatin sodium purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2024 May 29;13(6):667. [Abstract]

MIC assays and spotting assays show that erg11△/erg11△ was significantly sensitive to PIT (0-100 μM) compared to the wild-type strain.
Sci Data

High-throughput drug screening identifies novel therapeutics for Low Grade Serous Ovarian Carcinoma. [Abstract]

2024 Sep 19;11(1):1024. PMID: 39300112
Bioorg Chem

Dried tangerine peel polysaccharide (DTPP) alleviates hepatic steatosis by suppressing TLR4/MD-2-mediated inflammation and endoplasmic reticulum stress. [Abstract]

2024 Jun:147:107369. PMID: 38640721

Pitavastatin sodium purchased from MedChemExpress. Usage Cited in: Bioorg Chem. 2024 Jun:147:107369. [Abstract]

Oil red O staining and quantification of zebrafish liver after treatment with DTPP and Pitavastatin Calcium. Day1 of DTPP treatment.

Pitavastatin sodium purchased from MedChemExpress. Usage Cited in: Bioorg Chem. 2024 Jun:147:107369. [Abstract]

Oil red O staining and quantification of zebrafish liver after treatment with DTPP and Pitavastatin Calcium. Day3 of DTPP treatment.
Acta Biochim Biophys Sin (Shanghai)

Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis. [Abstract]

2024 Apr 25;56(4):621-633. PMID: 38516704
Research Square Preprint

2024 Apr 9.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Morikawa S, et al. Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells. J Atheroscler Thromb. 2000;7(3):138-44. [Content Brief]

[2]. Katsuki S, et al. Nanoparticle-mediated delivery of pitavastatin inhibits atherosclerotic plaque destabilization/rupture in mice by regulating the recruitment of inflammatory monocytes. Circulation. 2014 Feb 25;129(8):896-906. [Content Brief]

[3]. Tajiri K, et al. Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice. Cardiovasc Drugs Ther. 2013 Oct;27(5):413-24. [Content Brief]

[4]. Hamano T, et al. Pitavastatin decreases tau levels via the inactivation of Rho/ROCK. Neurobiol Aging. 2012 Oct;33(10):2306-20. [Content Brief]

[5]. de Wolf E, et al.Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer.Sci Rep. 2017 Jul 14;7(1):5410. [Content Brief]

[6]. Demir B, et al. The Effects of Pitavastatin on Nuclear Factor-Kappa B and ICAM-1 in Human Saphenous Vein Graft Endothelial Culture. Cardiovasc Ther. 2019 May 2;2019:2549432. [Content Brief]

[7]. Hayashi T, et al. A new HMG-CoA reductase inhibitor, pitavastatin remarkably retards the progression of high cholesterol induced atherosclerosis in rabbits. Atherosclerosis. 2004 Oct;176(2):255-63. [Content Brief]

[8]. Sahebkar A, et al. A comprehensive review on the lipid and pleiotropic effects of pitavastatin. Prog Lipid Res. 2021 Nov;84:101127. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Pitavastatin sodium

6 Cited Publications

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Pitavastatin sodium

Publications Citing Use of MedChemExpress (MCE) Pitavastatin sodium

Biologische Aktivität

Chemical Information

Publications (6)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Pitavastatin sodium Related Classifications

HY-B0144B Related Classifications