RIPK1-IN-37
RIPK1-IN-37 is an RIPK1 inhibitor and a ligand for the target protein for PROTAC LD5097 (HY-179234). RIPK1-IN-37 can be used to synthesize PROTAC.
(Pink: RIPK1 ligand (HY-179235); Blue: VHL ligand (HY-47070); Black: linker (HY-179236)).
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- CAS. Nr.: 2782024-39-7
- Formel: C28H27F3N6O2
- Molecular Weight:536.55
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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RIPK1 |
RIPK1 PROTAC contains two different ligands connected by a linker; one is an E3 ligase ligand, and the other is for Ligands of RIPK1 target protein (RIPK1-IN-37) (HY-179235). The Ligand-Linker conjunction (RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip) (HY-179242) formed by the ligation of Ligands and the linker can form PROTAC LD5097 (HY-179234) with the E3 ligase ligand. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2782024-39-7
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Molecular Weight 536.55
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Formel C28H27F3N6O2
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SMILES
O=C(N1CCC2=C1C=CC(C3=CN(C4=NC=NC(N)=C34)C5CCNCC5)=C2)CC6=CC=CC(OC(F)(F)F)=C6
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
RIPK1-IN-37 Related Classifications
HY-179235 Related Classifications
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