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S 15931

S 15931 is a 5-HT_1A receptor inhibitor. S 15931 inhibits the late-phase hindpaw licking response induced by formalin and the abdominal writhing response induced by acetic acid in Mus musculus. S 15931 abolishes the spontaneous tail-flick response induced by 8-OH-DPAT in Rattus norvegicus and potentiates the analgesic effect of morphine. S 15931 is applicable for pain-related research.

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CAS. Nr.: 153607-45-5
Formel: C₂₃H₂₈N₂O₂
Molecular Weight:364.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

S 15931 Chemical Structure

CAS. Nr.: 153607-45-5

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen :

In Vivo

S 15931 (40 mg/kg; s.c.; single administration; 30 min before testing) exerts stronger inhibitory efficacy on the late phase than the early phase of formalin-induced licking response in male NMRI mice^[1].
S 15931 (40 mg/kg; s.c.; single administration; 30 min before testing) inhibits acetic acid-induced writhing response in male NMRI mice^[1].
S 15931 (40 mg/kg; s.c.; single administration; 30 min before testing) induces rotarod ataxia in male NMRI mice^[1].
S 15931 (40 mg/kg; s.c.; single administration; administered 20 minutes prior to 8-OH-DPAT treatment) potently inhibits the spontaneous tail-flick response induced by 8-OH-DPAT (HY-112061) in male Wistar rats^[1].
S 15931 (0-10.0 mg/kg; s.c.; single administration; 60 min before testing) does not alter vocalization threshold on its own, but it enhances the analgesic effect of morphine in a dose-dependent manner in the electrically stimulated tail vocalization test in male Wistar rats, with a significant effect observed at doses ≥0.63 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NMRI (male, 20-25 g, formalin-induced hindpaw licking model)^[1]
Dosage:

40.0 mg/kg
Administration:

s.c.; single dose; 30 minutes pre-test
Result:

Achieved an ID₅₀ of 1.2 mg/kg for inhibition of the early phase of formalin-induced licking, producing a 95% maximum observed effect at 40.0 mg/kg.
Achieved an ID₅₀ of 0.3 mg/kg for inhibition of the late phase of formalin-induced licking, producing a 99% maximum observed effect at 40.0 mg/kg.

Animal Model:

NMRI (male, 20-25 g, acetic acid-induced abdominal writhing model)^[1]
Dosage:

40.0 mg/kg
Administration:

s.c.; single dose; 30 minutes pre-test
Result:

Achieved an ID₅₀ of 10.4 mg/kg for inhibition of acetic acid-induced writhing, producing a 93% maximum observed effect at 40.0 mg/kg.

Animal Model:

NMRI (male, 20-25 g, rotarod ataxia model)^[1]
Dosage:

40.0 mg/kg
Administration:

s.c.; single dose; 30 minutes pre-test
Result:

Achieved an ID₅₀ of 21.3 mg/kg for induction of rotarod ataxia, producing a 90% maximum observed effect at 40.0 mg/kg.

Animal Model:

Wistar (male, 200-250 g, 8-OH-DPAT-induced spontaneous tail-flicks model)^[1]
Dosage:

40.0 mg/kg
Administration:

s.c.; single dose; 20 minutes pre-8-OH-DPAT
Result:

Achieved an ID₅₀ of 0.7 mg/kg for inhibition of 8-OH-DPAT-induced spontaneous tail-flicks, producing a 99% maximum observed effect at 40.0 mg/kg.

Animal Model:

Wistar (male, 200-250 g, electrical tail stimulation vocalization model)^[1]
Dosage:

0.01, 0.04, 0.16, 0.83, 2.5, 10.0 mg/kg
Administration:

s.c.; single dose; 60 minutes pre-test
Result:

Did not significantly alter vocalization threshold relative to vehicle when administered alone.
Dose-dependently facilitated morphine's antinociceptive action, with significant potentiation observed at doses of 0.63 mg/kg, 2.5 mg/kg, and 10.0 mg/kg when co-administered with morphine.

Chemical Information

CAS. Nr. 153607-45-5
Molecular Weight 364.48
Formel C₂₃H₂₈N₂O₂
SMILES

C12=CC=CC(N3CCN(CCC4C5=C(CC4)C=CC=C5)CC3)=C1OCCO2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Millan MJ, et al. Pro- and antinociceptive actions of serotonin (5-HT)1A agonists and antagonists in rodents: relationship to algesiometric paradigm. Behav Brain Res. 1996;73(1-2):69-77. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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