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Art. -Nr.: HY-101313

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(S)-Remoxipride

(Synonyms: (-)-Remoxipride)

(S)-Remoxipride ((-)-Remoxipride) is a selective dopamine D₂-receptor antagonist with an IC₅₀ value of 1.57 μM. (S)-Remoxipride can be used for the research of psychotic disorder.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 80125-14-0
Formel: C₁₆H₂₃BrN₂O₃
Molecular Weight:371.27

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

(S)-Remoxipride Chemical Structure

CAS. Nr.: 80125-14-0

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

(S)-Remoxipride ((-)-Remoxipride) is a selective dopamine D₂-receptor antagonist with an IC₅₀ value of 1.57 μM. (S)-Remoxipride can be used for the research of psychotic disorder^[1].

IC₅₀ & Target

D₂ Receptor

1.57 μM (IC₅₀)

D₁ Receptor

＞100 μM (IC₅₀)

α₁-Adrenoccptor

42 μM (IC₅₀)

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

(S)-Remoxipride (1-100 μM; 20 min) shows binding efficiency with IC₅₀s of ＞100, 1.57 and 42 μM for dopamine D₁, dopamine D₂ and α₁-Adrenoccptor, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(S)-Remoxipride (0.1-100 μM/kg; i.p. 60 min prior to apomorphine) blockades apomorphine-induced behaviors s in rats and vomiting in dogs^[1].
(S)-Remoxipride (0.1-10 mg/kg; i.p. 30 min prior to apomorphine) displaces [³H]spiperone from both striatal and extra-striatal areas^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague-Dawley rats^[1]
Dosage:

0.1-100 μM/kg
Administration:

Intraperitoneal injection; 0.1-100 μM/kg; 60 min prior to apomorphine
Result:

Blocked apomorphine-induced hyperactivity and dose-dependent blockaded apomorphine-induced behaviors in vivo.

Animal Model:

Male and female beagle dogs^[1]
Dosage:

0.25-5 μM/kg
Administration:

Oral gavage; 0.25-5 μM/kg; 60 min prior to apomorphine
Result:

Blocked apomorphine-induced vomiting in dogs.

Chemical Information

CAS. Nr. 80125-14-0
Molecular Weight 371.27
Formel C₁₆H₂₃BrN₂O₃
SMILES

O=C(NC[C@H]1N(CC)CCC1)C2=C(OC)C=CC(Br)=C2OC
Synonyms

(-)-Remoxipride
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ogren SO, et al. Remoxipride, a new potential antipsychotic compound with selective antidopaminergic actions in the rat brain. Eur J Pharmacol. 1984 Jul 20;102(3-4):459-74. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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(S)-Remoxipride

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

(S)-Remoxipride Related Classifications

HY-101313 Related Classifications