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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
LPC
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "LPC" in MCE Product Catalog:
126
126 Publications Verification
Art. -Nr.: HY-P1410
CAS. Nr.: 1209500-46-8
Target:
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
126
126 Publications Verification
Art. -Nr.: HY-P1410A
Target:
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
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1 Cited Publications
Synonyms: 18:0 Lyso-PC; LPC(18:0)
Target:
Art. -Nr.: HY-N9410
CAS. Nr.: 22252-07-9
Synonyms: 1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC; LPC(18:2/0:0); LysoPC(18:2)
Category:
Infection Natural Products Disease markers Metabolic Disease Endocrine diseases Endogenous metabolite Disease Research Fields
Target:
Synonyms: BLD-0409; PAT-409
Target:
Forschungsgebiete:
Cudetaxestat (BLD-0409; PAT-409) is an orally active and noncompetitive autotaxin (ATX) inhibitor. Cudetaxestat inhibits the activity of ATX, reduces the production of LPA, and thereby blocks the signal transduction of the ATX-LPA axis. Cudetaxestat can still maintain nanomolar-level biochemical efficacy even when the concentration of the LPC substrate increases. Cudetaxestat can be used for the study of various diseases related to LPA including fibrosis, tumor metastasis, inflammation and autoimmune diseases, etc .
Art. -Nr.: HY-157700
CAS. Nr.: 97802-53-4
Synonyms: C16(Plasm) LPC; Lysophosphatidylcholine 16:0p/0:0
Target:
Forschungsgebiete:
Hexadecenyl-2-hydroxy-sn-glycero-3-PC (C16(Plasm) LPC) is a phosphatidylcholine. Hexadecenyl-2-hydroxy-sn-glycero-3-PC prolongs the lag-phase of α-syn aggregation, and can be used in Parkinson’s disease research .
Art. -Nr.: HY-W020809
CAS. Nr.: 97802-55-6
Synonyms: PC(18:1p/0:0)
Target:
Forschungsgebiete:
C18(Plasm) LPC (PC(18:1p/0:0)) is classified as a type of plasmalogen.
Art. -Nr.: HY-126233
CAS. Nr.: 1689554-51-5
Target:
Forschungsgebiete:
PAT-347 is an inhibitor of autotaxin (ATX, ENPP-2) . PAT-347 binds only to the hydrophobic channel of ATX, without occupying its hydrophobic pocket and catalytic site . PAT-347 blocks the binding of lysophosphatidylcholine (LPC) to the catalytic site of ATX .
Art. -Nr.: HY-125771S
CAS. Nr.: 327178-92-7
Synonyms: 18:0 Lyso-PC-d35; LPC(18:0)-d35
Art. -Nr.: HY-173509
CAS. Nr.: 2023027-81-6
Target:
Forschungsgebiete:
Infection Cardiovascular Disease Neurological Disease Cancer
ATX inhibitor 27 (Compound 31) is an ATX inhibitor. The IC50 values of ATX inhibitor 27 against human autotaxin (hATX) and lysophosphatidylcholine (LPC) are 13 nM and 23 nM, respectively. ATX inhibitor 27 reduces LPA levels in vivo by inhibiting ATX enzyme. ATX inhibitor 27 can be used in the study of ATX-LPA-related diseases such as inflammation, neurodegenerative diseases and cancer .
Art. -Nr.: HY-RS10176
Target:
Forschungsgebiete:
PCSK7 Human Pre-designed siRNA Set A contains three designed siRNAs for PCSK7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-149716
CAS. Nr.: 3047891-88-0
Target:
Forschungsgebiete:
MEY-003 is an Autotaxin(ATX) inhibitor with EC50s of 460 nM and 1.09 μM for hATX-β and hATX-ɣ (analysis with LPC18:1). MEY-003 behaves as a non-competitive inhibitor with K iof 432 nM. MEY-003 can be used for targeted ATX-related disease research .
Art. -Nr.: HY-134954
CAS. Nr.: 910228-13-6
Target:
Forschungsgebiete:
Palmitoleoyl 3-carbacyclic phosphatidic acid (3ccPA 16:1) is an intermediately potent inhibitor of autotaxin (ATX) with an IC50 of 620 nM. Palmitoleoyl 3-carbacyclic phosphatidic acid can be used for melanoma research .
Art. -Nr.: HY-160581
CAS. Nr.: 496801-51-5
OH-C-Chol is a cationic liposome that serves as a siRNA delivery vehicle. OH-C-Chol (LP-C) and OH-NC-Chol (LP-NC)/siRNA complexes (lipoplexes) showed better performance than NP-C and NP-NC/siRNA complexes (nanocomplexes), respectively. ) greater gene silencing effect .
Art. -Nr.: HY-120633
CAS. Nr.: 1622180-31-7
Target:
BMS-986104 is a potent and selective S1P1 receptor modulator. BMS-986104 is effective in a mouse EAE model, which is comparable to FTY720. Mechanistically, BMS-986104 exhibites excellent remyelinating effects on lysophosphatidylcholine (LPC)-induced demyelination in a three-dimensional brain cell culture assay.
Art. -Nr.: HY-126233A
CAS. Nr.: 2650082-35-0
Target:
Forschungsgebiete:
PAT-347 sodium is an Autotaxin (ATX) inhibitor. ATX is a secretory enzyme that hydrolyzes lysophosphatidylcholine (LPC) and regulates lysophosphatidic acid (LPA) production in the blood .
Art. -Nr.: HY-119601
CAS. Nr.: 313685-55-1
Target:
Forschungsgebiete:
GRI918013 (compound 1) is a selective and competitive autotaxin (ATX/NPP2) inhibitor with anti-invasive and anti-metastatic activity. GRI918013 competitively binds to ATX, blocking lipid substrates such as lysophosphatidylcholine (LPC) from entering the ATX active site, thereby inhibiting ATX-mediated hydrolysis of LPC to lysophosphatidic acid (LPA), and consequently inhibiting ATX-LPA axis-related tumor cell invasion and metastasis. GRI918013 inhibits ATX-mediated hydrolysis of the LPL substrate FS-3 (IC50=31.42 nM, Ki=12.98 nM). GRI918013 can be used in research on cancer invasion and metastasis, such as melanoma, and can also serve as a tool compound for ATX-LPA axis-related diseases such as fibrotic diseases, neuropathic pain, and cholestatic pruritus .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
