1782070-21-6
Chemical Structure
Cudetaxestat
Synonym(s): BLD-0409; PAT-409
- CAS No.: 1782070-21-6
- Formula:C21H15Cl2F2N3O2S
- Molecular Weight:482.33
IUPAC Name: 3-((2,6-dichloro-7-fluoro-1-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-yl)thio)-2-fluorobenzoic acid
InChIKey: NMDFAQXLJQRHMS-UHFFFAOYSA-N
SMILES: O=C(C1=C(F)C(SC2=C(N(C3=C2C=CC(Cl)=C3F)C4=CN(CCC)N=C4)Cl)=CC=C1)O
Biological Activity: Cudetaxestat (BLD-0409; PAT-409) is an orally active and noncompetitive autotaxin (ATX) inhibitor. Cudetaxestat inhibits the activity of ATX, reduces the production of LPA, and thereby blocks the signal transduction of the ATX-LPA axis. Cudetaxestat can still maintain nanomolar-level biochemical efficacy even when the concentration of the LPC substrate increases. Cudetaxestat can be used for the study of various diseases related to LPA including fibrosis, tumor metastasis, inflammation and autoimmune diseases, etc[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cudetaxestat | 98.32% | Cudetaxestat (BLD-0409; PAT-409) is an orally active and noncompetitive autotaxin (ATX) inhibitor. Cudetaxestat inhibits the activity of ATX, reduces the production of LPA, and thereby blocks the signal transduction of the ATX-LPA axis. Cudetaxestat can still maintain nanomolar-level biochemical efficacy even when the concentration of the LPC substrate increases. Cudetaxestat can be used for the study of various diseases related to LPA including fibrosis, tumor metastasis, inflammation and autoimmune diseases, etc. | ||||||||||||||||||||
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- [1]. Tan Z, et al. An updated patent review of autotaxin inhibitors (2017-present). Expert Opin Ther Pat. 2021;31(5):421-434. [Content Brief]
- [2]. Wong, Carol, et al. Differentiating characteristics of cudetaxestat (BLD-0409), a non-competitive autotaxin inhibitor under development to treat idiopathic pulmonary fibrosis. D29. Mechanisms In Lung Injury, Repair, And Fibrosis. American Thoracic Society, 2022. A5234-A5234.
Keywords
