1689554-51-5
1689554-51-5
Chemical Structure
PAT-347
- CAS No.: 1689554-51-5
- Formula:C28H21ClF2N2O3S
- Molecular Weight:538.99
IUPAC Name: 3-((6-chloro-7-fluoro-2-methyl-1-(2-oxo-2-(spiro[cyclopropane-1,3'-indolin]-1'-yl)ethyl)-1H-indol-3-yl)thio)-2-fluorobenzoic acid
InChIKey: YFALJJNRFPFPRE-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=CC(SC2=C(C)N(CC(N3CC4(C5=C3C=CC=C5)CC4)=O)C6=C2C=CC(Cl)=C6F)=C1F
Biological Activity: PAT-347 is an Autotaxin (ATX) inhibitor. ATX is a secretory enzyme that hydrolyzes lysophosphatidylcholine (LPC) and regulates lysophosphatidic acid (LPA) production in the blood[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PAT-347 | 98.63% | PAT-347 is an Autotaxin (ATX) inhibitor. ATX is a secretory enzyme that hydrolyzes lysophosphatidylcholine (LPC) and regulates lysophosphatidic acid (LPA) production in the blood. | ||||||||||||||||||||
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References
- [1]. Chen Y, et al. Design, synthesis and anti-fibrosis evaluation of imidazo [1, 2–a] pyridine derivatives as potent ATX inhibitors[J]. Bioorganic & Medicinal Chemistry, 2021, 46: 116362.
- [2]. Joncour A, et al. Discovery, structure–activity relationship, and binding mode of an imidazo [1, 2-a] pyridine series of autotaxin inhibitors[J]. Journal of Medicinal Chemistry, 2017, 60(17): 7371-7392.
Keywords
