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Art. -Nr.: HY-178158

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SQS-IN-1

SQS-IN-1 is a squalene synthase (SQS) inhibitor. SQS-IN-1 exhibits potent and broad-spectrum anti-proliferative effects on both mouse and human lung cancer cell lines. SQS-IN-1 inhibits DNA replication and the cell cycle, causing mitochondrial hyperpolarization and inducing cell apoptosis. SQS-IN-1 inhibits cell migration and invasion. SQS-IN-1 can be used to the study of lung cancer.

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CAS. Nr.: 2306302-57-6
Formel: C₂₄H₂₇BrN₂O₅
Molecular Weight:503.39

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

SQS-IN-1 Chemical Structure

CAS. Nr.: 2306302-57-6

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Biologische Aktivität

Beschreibung

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

SQS-IN-1 (Compound 2) (0.1 nM-100 μM, 24-72 h) inhibits various lung cancer cell lines proliferation including LLCOVA cells, NSCLC cell lines (H1299 and H358) and B16 melanoma cells and with TC₅₀s of 3.21 nM, 1.6 μM, 0.55 μM and 0.21 μM at 72 h^[1].
SQS-IN-1 (10 and 0.1 μM, 24 h) induces G0/G1 phase arrest in A549 cells and arrested DNA replication in LLC-OVA cells^[1].
SQS-IN-1 (0.1 μM, 24 h) induces LLC-OVA cells apoptosis and effectively inhibits the metastasis ability of cancer cells^[1].
SQS-IN-1 (0-10 μM) causes mitochondrial hyperpolarization in a dose-dependent manner in LLC-OVA cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

A549 and LLC-OVA cells
Concentration:

10 μM (A549) and 0.1 μM (LLC-OVA)
Incubation Time:

24 h
Result:

Significantly reduced the proportion of cells in the S phase and the G2 phase, resulting in the accumulation of cells in the G0/G1 phase in A549 cells.
Inhibited DNA replication and the cell cycle progression in LLC-OVA.

Apoptosis Analysis^[1]

Cell Line:

LLC-OVA cells
Concentration:

0.1 μM
Incubation Time:

24 h
Result:

Significantly increased the percentage of cells in the early apoptotic stage.

Cell Migration Assay ^[1]

Cell Line:

LLC-OVA cells
Concentration:

0.1 μM
Incubation Time:

24 h
Result:

Reduced the wound closure rate of LLC-OVA cells by approximately 23%.

Cell Invasion Assay^[1]

Cell Line:

LLC-OVA cells
Concentration:

0.1 μM
Incubation Time:

24 h
Result:

Reduced the invasive ability of LLC-OVA cells by 25%.

Chemical Information

CAS. Nr. 2306302-57-6
Molecular Weight 503.39
Formel C₂₄H₂₇BrN₂O₅
SMILES

CN1CCOC(C2=CC=C(C3=CC=C(C=CC=C4)C4=C3)C=C2)(OCCCO[N+]([O-])=O)C1.Br
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Katavati, Theodora, et al. Unraveling the Potential Pathogenic Role of Squalene Synthase (SQS) in Lung Cancer Using Enzyme Inhibitors as Molecular Tools. ACS Medicinal Chemistry Letters (2025).

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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SQS-IN-1

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

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SQS-IN-1 Related Classifications

HY-178158 Related Classifications