TDP-665759
TDP-665759 is an inhibitor for HDm2:p53 complex, and thus activates p53, inhibits STAT3 signaling pathway (EC50 of 5.90 μM) and the cell viability of p53 expressing A549R (IC50 of 7.02 μM). TDP-665759 induces apoptosis in HepG2. TDP-665759 exhibits antitumor efficacy in mouse models.
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- CAS. Nr.: 787632-66-0
- Formel: C31H34Cl2IN5O2
- Molecular Weight:706.44
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
0.8 μM
Compound: 12k
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Antiproliferative activity against wild type p53 MCF7 cell line
Antiproliferative activity against wild type p53 MCF7 cell line
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[PMID: 16630722] |
| MDA-MB-231 | IC50 |
8 μM
Compound: 12k
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Antiproliferative activity against mutant p53 MDA-MB-231 cell line
Antiproliferative activity against mutant p53 MDA-MB-231 cell line
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[PMID: 16630722] |
Chemical Information
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CAS. Nr. 787632-66-0
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Molecular Weight 706.44
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Formel C31H34Cl2IN5O2
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SMILES
O=C([C@H](C1=CC=C(Cl)C=C1)N2[C@@H](C3=CC=C(Cl)C=C3N)C)N(CCCN4CCN(C)CC4)C5=CC=C(I)C=C5C2=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
TDP-665759 Related Classifications
HY-18329 Related Classifications
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