ZZ7-23-022
ZZ7-23-022 (ZZ7) is a selective BRD9 molecule glue degrader. ZZ7-23-022 effectively degrades BRD9 in synovial sarcoma cells, but does not affect cardiomyocytes. ZZ7-23-022 can be used for the research of cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C36H45N7O5
- Molecular Weight:655.79
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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BRD9 |
ZZ7-23-022 (0.1-3 μM, 5 h) degrades BRD9 in a dose-dependent manner in Jurkat cells[1].
ZZ7 (0.05-0.5 μM, 5 h) effectively degrades BRD9 in synovial sarcoma cells (CME-1, HS-SY-II, 1273/99), but does not affect cardiomyocytes[1].
ZZ7 (0.1-3 μM, 5 h) fails to degrade BRD9 in DCAF16-knockout (DCAF16-/-) Jurkat/K-562 cells and also loses degradation activity in DCAF16-Cys178 mutant cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 655.79
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Formel C36H45N7O5
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SMILES
CC(N1CCN(C2COC2)CC1)(C)/C=C(C(N3CCN(CC4=C(OC)C=C(C(C5=CC=NC=C65)=CN(C)C6=O)C=C4OC)CC3)=O)\C#N
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Synonyms
ZZ7
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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