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Cat. No.: HY-N19854

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Mariaterpenoside A

Mariaterpenoside A is an inducible nitric oxide synthase (iNOS) inhibitor. Mariaterpenoside A interacts with the active cavity of iNOS protein via hydrogen bonds with specific residues of the binding site. Mariaterpenoside A suppresses NO release in LPS (HY-D1056)-induced murine microglial BV-2 cells. Mariaterpenoside A can be used for the research of neurodegenerative disease.

For research use only. We do not sell to patients.

CAS No.: 2097442-40-3
Formula: C₁₆H₂₄O₈
Molecular Weight:344.36

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Please store the product under the recommended conditions in the Certificate of Analysis.

Mariaterpenoside A Chemical Structure

CAS No.: 2097442-40-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

iNOS

All NO Synthase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	14.1 μM Compound: 3	Inhibition of LPS-induced NO production in mouse BV2 cells after 20 hrs by Griess assay Inhibition of LPS-induced NO production in mouse BV2 cells after 20 hrs by Griess assay	[PMID: 28377060]

In Vitro

Mariaterpenoside A (Compound 3) potently inhibits LPS-induced NO production in murine microglial BV-2 cells with an IC₅₀ of 14.1 μM without significant cytotoxicity^[1].
Mariaterpenoside A interacts with the active cavity of iNOS protein (PDB code: 3E6T) with a binding energy of -8.28 kcal/mol, targeting residues GLY-365, TYR-367, GLU-371, PRO-344, and TRP-366^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2097442-40-3
Molecular Weight 344.36
Formula C₁₆H₂₄O₈
SMILES

O[C@H]1[C@H](OC2=C(CO)C=CC(C(C)(C)O)=C2)O[C@H](CO)[C@@H](O)[C@@H]1O
Structure Classification
- Saccharides
- Monosaccharides
Initial Source
- Plants
- Compositae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Qin NB, et al. Bioactive terpenoids from Silybum marianum and their suppression on NO release in LPS-induced BV-2 cells and interaction with iNOS. Bioorg Med Chem Lett. 2017;27(10):2161-2165. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Mariaterpenoside A

All NO Synthase Isoforms