(Z)-Isbogrel
(Z)-Isbogrel ((Z)-CV-4151) is a potent thromboxane A2 (TxA2) synthase inhibitor with an IC50 of 0.9 nM. (Z)-Isbogrel inhibits serum TxB2 production, with an ED50 of 0.01 mg/kg upon intravenous administration and an ED50 of 0.05 mg/kg upon oral administration in rats, and it exhibits no PAF receptor antagonistic activity. (Z)-Isbogrel can be used in research related to cardiovascular and cerebrovascular diseases.
For research use only. We do not sell to patients.
- CAS No.: 89667-39-0
- Formula: C18H19NO2
- Molecular Weight:281.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TXA2 0.9 nM (IC50) |
(Z)-Isbogrel potently inhibits thromboxane A2 synthase activity in human platelet microsomes. When TxB2 production is measured using PGH2 as the substrate, the IC50 value is 0.9 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 89667-39-0
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Molecular Weight 281.36
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Formula C18H19NO2
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SMILES
C(=C/CCCCC(O)=O)(\C1=CC=CC=C1)/C=2C=CC=NC2
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Synonyms
(Z)-CV-4151
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Z)-Isbogrel Related Classifications
HY-119890A Related Classifications
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