89667-39-0
Chemical Structure
(Z)-Isbogrel
Synonym(s): (Z)-CV-4151
- CAS No.: 89667-39-0
- Formula:C18H19NO2
- Molecular Weight:281.36
IUPAC Name: (Z)-7-phenyl-7-(pyridin-3-yl)hept-6-enoic acid
InChIKey: UWPBQLKEHGGKKD-BOPFTXTBSA-N
SMILES: C(=C/CCCCC(O)=O)(\C1=CC=CC=C1)/C=2C=CC=NC2
Biological Activity: (Z)-Isbogrel ((Z)-CV-4151) is a potent thromboxane A2 (TxA2) synthase inhibitor with an IC50 of 0.9 nM. (Z)-Isbogrel inhibits serum TxB2 production, with an ED50 of 0.01 mg/kg upon intravenous administration and an ED50 of 0.05 mg/kg upon oral administration in rats, and it exhibits no PAF receptor antagonistic activity. (Z)-Isbogrel can be used in research related to cardiovascular and cerebrovascular diseases[1].
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(Z)-Isbogrel | (Z)-Isbogrel ((Z)-CV-4151) is a potent thromboxane A2 (TxA2) synthase inhibitor with an IC50 of 0.9 nM. (Z)-Isbogrel inhibits serum TxB2 production, with an ED50 of 0.01 mg/kg upon intravenous administration and an ED50 of 0.05 mg/kg upon oral administration in rats, and it exhibits no PAF receptor antagonistic activity. (Z)-Isbogrel can be used in research related to cardiovascular and cerebrovascular diseases. | |||||||||||||||||||||
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