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CX-5461 dihydrochloride

71 Cited Publications
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Based on 71 publication(s) in Google Scholar

CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ≥25 μM).

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  • Pureté: 99.41%
  • Formule: C27H29Cl2N7O2S
  • Masse moléculaire:586.54
  • Stockage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)

  • CX-5461 dihydrochloride Chemical Structure
    CX-5461 dihydrochloride Chemical Structure
  • Experimental Validation Results for CX-5461 dihydrochloride
  • Experimental Validation Results for CX-5461 dihydrochloride
  • Experimental Validation Results for CX-5461 dihydrochloride
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Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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  • CX-5461 dihydrochloride Chemical Structure
    CX-5461 dihydrochloride Chemical Structure
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    CX-5461 dihydrochloride purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2017 Nov 1;23(21):6529-6540. [Abstract]

    Customer Validation
     Western blot analysis verifying G2/M phase arrest in 6 cell lines. Treatment with IC50 dosages of CX-5461 shows an increase in expression of pCDC2(tyr15) and Cyclin-B versus untreated controls at 72 hours.

  • 1/16

    CX-5461 dihydrochloride purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2017 Nov 1;23(21):6529-6540. [Abstract]

    Customer Validation
     Western blot analysis shows activation of the pCHK1(ser317) and pCHK2(T68), downstream substrates of ATM and ATR kinases. TP53 wild type cell lines show a subsequent activation of p21 but drug response is independent of TP53 status.

  • 1/16

    CX-5461 dihydrochloride purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Oct 29;8(57):96536-96552. [Abstract]

    Customer Validation
     Protein levels of HCMV IE (IE1:IE72, IE2:IE86) and pp65 are detected by WB analysis in untreated and pre-treated HCMV infected cells 72hpi.

  • CX-5461 dihydrochloride