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Cat. No.: HY-181503

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AChE/BuChE-IN-8

AChE/BuChE-IN-8 is a dual AChE and BuChE inhibitor, with an AChE IC₅₀ of 1.18 μM, a human AChE K_i of 1.2 μM, and a BuChE IC₅₀ of 2.34 μM. AChE/BuChE-IN-8 acts as an antiproliferative agent and antioxidant, exerts antiproliferative effects on colon cancer cells, scavenges free radicals, and exhibits reducing power. AChE/BuChE-IN-8 can be used in the research of Alzheimer's disease and colorectal adenocarcinoma.

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Formule: C₂₄H₁₈F₂N₆O₂
Masse moléculaire:460.44

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

AChE/BuChE-IN-8 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

AChE

1.18 μM (IC₅₀)

AChE

1.2 μM (Ki)

BuChE

2.34 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform Cholinesterase (ChE) :

AChE
BChE

In Vitro

AChE/BuChE-IN-8 (Compound 6d) is a mixed-type hAChE inhibitor that binds to both free enzyme and enzyme-substrate complex simultaneously. It exhibits an AChE IC₅₀ of 1.18 μM and a BuChE IC₅₀ of 2.34 μM, with synergistic competitive (K_i = 1.2 μM) and non-competitive (K_i' = 2.5 μM) inhibitory effects^[1].
AChE/BuChE-IN-8 (48 h) exhibits moderate antiproliferative activity against Caco-2 colon cancer cells (IC₅₀ = 4.37 μM), with a selectivity index of 7.43^[1].
AChE/BuChE-IN-8 exhibits potent free radical scavenging activity (IC₅₀ = 12.1 μM).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 460.44
Formule C₂₄H₁₈F₂N₆O₂
SMILES

FC1=CC=C(N2C=C(COC3=CC=C(OCC4=CN(C5=CC=C(F)C=C5)N=N4)C=C3)N=N2)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Onur S, et al. Multifunctional hydroquinone-1,2,3-triazole hybrids: Synthesis, biological evaluation, molecular docking, ADMET profiling, and in silico mechanistic insights as potential therapeutic agents. Bioorg Chem. 2026;170:109548. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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Cat. No.:
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AChE/BuChE-IN-8

Voir tous les produits spécifiques à Isoform Cholinesterase (ChE)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

AChE/BuChE-IN-8 Related Classifications

HY-181503 Related Classifications