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Cat. No.: HY-144585

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AGD-0182

AGD-0182 is a microtubule disrupting agent. AGD-0182 is a synthetic analogue of the naturally occurring tubulin-binding molecule Dolastatin 10. AGD-0182 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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CAS No.: 1835700-14-5
Formule: C₃₈H₆₃N₉O₇
Masse moléculaire:757.96

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

AGD-0182 Chemical Structure

CAS No.: 1835700-14-5

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

AGD-0182 is a microtubule disrupting agent. AGD-0182 is a synthetic analogue of the naturally occurring tubulin-binding molecule Dolastatin 10^[1]. AGD-0182 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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Cellular Effect

Cell Line	Type	Value	Description	References
KARPAS-299	IC₅₀	0.6 nM Compound: 83a	Cytotoxicity against human KARPAS-299 cells assessed as reduction in cell viability incubated for 5 days by Presto blue dye based assay Cytotoxicity against human KARPAS-299 cells assessed as reduction in cell viability incubated for 5 days by Presto blue dye based assay	[PMID: 35072477]

Chemical Information

CAS No. 1835700-14-5
Masse moléculaire 757.96
Formule C₃₈H₆₃N₉O₇
SMILES

CN[C@@H](C(C)C)C(N[C@@H]([C@H](C)N=[N+]=[N-])C(N(C)[C@@H]([C@@H](C)CC)[C@@H](CC(N1[C@@H](CCC1)[C@H](OC)[C@@H](C)C(N[C@H](C(N)=O)CC2=CC=CC=C2)=O)=O)OC)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Snyder JT, et al. Metabolism of an Oxime-Linked Antibody Drug Conjugate, AGS62P1, and Characterization of Its Identified Metabolite. Mol Pharm. 2018;15(6):2384-2390. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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AGD-0182

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