AS1-6
AS1-6 is a selective COX-2 inhibitor with an IC50 of 2.7 μM. AS1-6 has an IC50 of 12.6 μM for COX-1. AS1-6 exerts significant anti-inflammatory and analgesic activities. AS1-6 can be used in research on non-steroidal anti-inflammatory agents.
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- Formule: C23H17ClFNO3
- Masse moléculaire:409.84
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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COX-2 2.7 μM (IC50) |
COX-1 12.6 μM (IC50) |
AS1-6 (10-200 μg/mL; 24 h) shows low toxicity to brine shrimp, with an LD50 > 200 μg/mL[1].
AS1-6 (30 μg/mL; 24-48 h) shows no activity against 3T3 fibroblasts, indicating its low toxicity toward non-cancerous cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Albino mice (adult male and female, 6-7 weeks old, 25-30 g)[1]
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Dosage:10 mg/kg
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Administration:i.p.; single dose
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Result:Significantly reduced paw thickness to 4.00 mm and COX-2 protein levels in the carrageenan-induced paw edema model.
Remarkably suppressed nociceptive behaviors in both the early phase and late phase, indicating both peripheral and central antinociceptive activity in formalin-induced paw licking test.
Significantly decreased the number of writhing responses in the acetic acid-induced writhing test.
Chemical Information
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Masse moléculaire 409.84
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Formule C23H17ClFNO3
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SMILES
O=C(NC1=CC=C(F)C=C1)COC2=CC=C(C(/C=C/C3=CC=CC=C3Cl)=O)C=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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