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Cat. No.: HY-N16714

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Clausine K

Clausine K is a carbazole alkaloid anticancer agent. Clausine K exhibits strong cytotoxicity against human hepatoma HepG2 cells (IC₅₀ = 1.05 μg/mL), superior to the standard drug Etoposide (HY-13629) (IC₅₀ 13.40 μg/mL). Clausine K can be naturally extracted from the dried stems of Clausena excavata (a plant of the Rutaceae family) through chromatographic separation and other methods.

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CAS No.: 182261-96-7
Formule: C₁₅H₁₃NO₄
Masse moléculaire:271.27

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Clausine K Chemical Structure

CAS No.: 182261-96-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	4.6 μM Compound: 55	Inhibition of NO production in LPS-stimulated mouse BV-2 cells preincubated with compound for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent-based assay Inhibition of NO production in LPS-stimulated mouse BV-2 cells preincubated with compound for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent-based assay	[PMID: 33454546]

Chemical Information

CAS No. 182261-96-7
Masse moléculaire 271.27
Formule C₁₅H₁₃NO₄
SMILES

O=C(C1=C(OC)C=C(NC2=C3C=CC(OC)=C2)C3=C1)O
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chakthong S, et al. Carbazole-pyranocoumarin conjugate and two carbazole alkaloids from the stems of Clausena excavata. Nat Prod Res. 2016 Aug;30(15):1690-7. [Content Brief]

Calculators

Calculateur de molarité

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Molecular Weight Molecular Weight

Calculateur de dilution

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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