Nrp1 - neuropilin 1 Gene

Also Known as Nrp; NP-1; Npn1; NPN-1; C530029I03

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18186

Summary

Enables protein kinase binding activity; transmembrane signaling receptor activity; and vascular endothelial growth factor binding activity. Involved in several processes, including nervous system development; regulation of signal transduction; and vasculature development. Acts upstream of or within several processes, including morphogenesis of a branching epithelium; nervous system development; and toxin transport. Located in several cellular components, including endosome; focal adhesion; and neurofilament. Is integral component of postsynaptic membrane. Is expressed in several structures, including cardiovascular system; jaw; lung; nervous system; and sensory organ. Used to study retinal vein occlusion. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human NRP1 (neuropilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Nrp1 Products (3)

mRNA	Protein	Name
NM_001358959.1	NP_001345888.1	neuropilin-1 isoform 2 precursor
NM_001358960.1	NP_001345889.1	neuropilin-1 isoform 3 precursor
NM_008737.2	NP_032763.2	neuropilin-1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables growth factor binding	IPI IPI: Inferred from physical interaction	10705382	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10520994	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	22683681	MGI
enables semaphorin receptor activity	IDA IDA: Inferred from direct assay	15239958	MGI
enables semaphorin receptor activity	IGI IGI: Inferred from genetic interaction	12591607	MGI
enables semaphorin receptor activity	IPI IPI: Inferred from physical interaction	15239958	MGI
enables vascular endothelial growth factor binding	IPI IPI: Inferred from physical interaction	24401374	MGI
enables vascular endothelial growth factor receptor activity	IMP IMP: Inferred from mutant phenotype	21658587	MGI

Biological Process GO Annotation	Evidence	Références	Source
involved in VEGF-activated neuropilin signaling pathway	IMP IMP: Inferred from mutant phenotype	21658587	MGI
involved in angiogenesis	IGI IGI: Inferred from genetic interaction	23639442	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	12852851	MGI
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	24401374	MGI
involved in angiogenesis involved in coronary vascular morphogenesis	IMP IMP: Inferred from mutant phenotype	24401374	MGI
involved in artery morphogenesis	IMP IMP: Inferred from mutant phenotype	23639442	MGI
acts upstream of axon extension	IGI IGI: Inferred from genetic interaction	12852851	MGI
acts upstream of axon extension involved in axon guidance	IDA IDA: Inferred from direct assay	9753685	MGI
involved in axon extension involved in axon guidance	IMP IMP: Inferred from mutant phenotype	22790009	MGI
acts upstream of or within axon guidance	IDA IDA: Inferred from direct assay	15814794	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	12852851	MGI
acts upstream of or within axonal fasciculation	IMP IMP: Inferred from mutant phenotype	17428830	MGI
involved in axonogenesis involved in innervation	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in basal dendrite arborization	IGI IGI: Inferred from genetic interaction	22683681	MGI
involved in basal dendrite development	IMP IMP: Inferred from mutant phenotype	22683681	MGI
acts upstream of or within blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	15376331	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	17428830	MGI
involved in branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	21852397	MGI
involved in branchiomotor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	18804103	MGI
NOT involved in cardiac neural crest cell migration involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	26053665	MGI
involved in cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	23315162	MGI
involved in cellular response to vascular endothelial growth factor stimulus	IMP IMP: Inferred from mutant phenotype	24401374	MGI
involved in commissural neuron axon guidance	IMP IMP: Inferred from mutant phenotype	21658587	MGI
involved in coronary artery morphogenesis	IMP IMP: Inferred from mutant phenotype	23639442	MGI
acts upstream of or within dendrite development	IMP IMP: Inferred from mutant phenotype	12852851	MGI
acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching	IGI IGI: Inferred from genetic interaction	17626059	MGI
acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching	IMP IMP: Inferred from mutant phenotype	17626059	MGI
involved in dorsal root ganglion morphogenesis	IMP IMP: Inferred from mutant phenotype	19386662	MGI
involved in endothelial cell migration	IMP IMP: Inferred from mutant phenotype	24863063	MGI
involved in facial nerve structural organization	IMP IMP: Inferred from mutant phenotype	18356247	MGI
involved in facioacoustic ganglion development	IMP IMP: Inferred from mutant phenotype	18356247	MGI
involved in gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IMP IMP: Inferred from mutant phenotype	21059704	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	12852851	MGI
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24863063	MGI
involved in motor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	18804103	MGI
involved in motor neuron migration	IMP IMP: Inferred from mutant phenotype	26503042	MGI
acts upstream of or within negative regulation of axon extension	IGI IGI: Inferred from genetic interaction	12852851	MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance	IDA IDA: Inferred from direct assay	9753685	MGI
involved in negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21828096	MGI
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	21828096	MGI
involved in neural crest cell migration involved in autonomic nervous system development	IMP IMP: Inferred from mutant phenotype	18356247	MGI
involved in neuron development	IMP IMP: Inferred from mutant phenotype	21828096	MGI
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in neuropilin signaling pathway	IMP IMP: Inferred from mutant phenotype	24863063	MGI
involved in otic placode development	IMP IMP: Inferred from mutant phenotype	18356247	MGI
involved in outflow tract septum morphogenesis	IMP IMP: Inferred from mutant phenotype	26053665	MGI
involved in positive chemotaxis	IMP IMP: Inferred from mutant phenotype	21658587	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	23639442	MGI
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	24863063	MGI
involved in positive regulation of axon extension involved in axon guidance	IMP IMP: Inferred from mutant phenotype	21658587	MGI
involved in positive regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	26051942	MGI
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	24863063	MGI
involved in positive regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	26051942	MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	23639442	MGI
involved in positive regulation of phosphorylation	IMP IMP: Inferred from mutant phenotype	24863063	MGI
involved in postsynapse organization	IDA IDA: Inferred from direct assay	16540575	MGI
involved in postsynapse organization	IMP IMP: Inferred from mutant phenotype	16540575	MGI
involved in protein localization to early endosome	IMP IMP: Inferred from mutant phenotype	23639442	MGI
involved in regulation of Cdc42 protein signal transduction	IMP IMP: Inferred from mutant phenotype	26051942	MGI
acts upstream of or within regulation of axon extension involved in axon guidance	IDA IDA: Inferred from direct assay	15814794	MGI
involved in renal artery morphogenesis	IMP IMP: Inferred from mutant phenotype	23639442	MGI
acts upstream of or within retina vasculature development in camera-type eye	IMP IMP: Inferred from mutant phenotype	25414188	MGI
involved in retina vasculature morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	24401374	MGI
involved in retinal ganglion cell axon guidance	IMP IMP: Inferred from mutant phenotype	21658587	MGI
acts upstream of or within semaphorin-plexin signaling pathway	IDA IDA: Inferred from direct assay	15239958	MGI
acts upstream of or within semaphorin-plexin signaling pathway	IGI IGI: Inferred from genetic interaction	12591607	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	18804103	MGI
involved in sensory neuron axon guidance	IMP IMP: Inferred from mutant phenotype	18356247	MGI
involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	24401374	MGI
involved in sympathetic ganglion development	IMP IMP: Inferred from mutant phenotype	19325129	MGI
acts upstream of or within sympathetic nervous system development	IMP IMP: Inferred from mutant phenotype	15814794	MGI
involved in sympathetic neuron projection extension	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in sympathetic neuron projection guidance	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in trigeminal ganglion development	IMP IMP: Inferred from mutant phenotype	18356247	MGI
acts upstream of or within trigeminal nerve morphogenesis	IMP IMP: Inferred from mutant phenotype	15814794	MGI
involved in trigeminal nerve structural organization	IMP IMP: Inferred from mutant phenotype	18804103	MGI
acts upstream of or within vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12852851	MGI
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23639442	MGI
involved in ventral trunk neural crest cell migration	IMP IMP: Inferred from mutant phenotype	19386662	MGI
involved in vestibulocochlear nerve structural organization	IMP IMP: Inferred from mutant phenotype	18356247	MGI

Cellular Component GO Annotation	Evidence	Références	Source
located in axon	IDA IDA: Inferred from direct assay	15677725	MGI
located in early endosome	IDA IDA: Inferred from direct assay	23639442	MGI
located in focal adhesion	IDA IDA: Inferred from direct assay	24863063	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16540575	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	16540575	MGI
located in neurofilament	IDA IDA: Inferred from direct assay	15814794	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	22683681	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	23639442	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	16540575	MGI
located in sorting endosome	IDA IDA: Inferred from direct assay	23639442	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
neuropilin-1	A5 protein Neuropilin-1 precursor (A5 protein) transmembrane receptor

Recombinant Nrp1 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P70401	Neuropilin-1 Protein, Mouse (HEK293, His)	P97333 (F22-P856)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73312	Neuropilin-1 Protein, Mouse (HEK293, Fc)	P97333 (F22-P856)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P3449A	Dazdotuftide TFA	Inhibitor	/	Phase 3
HY-P3448	Certepetide	Activator	99.80%	Phase 2

Inhibitory Antibodies (2)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P99386	Vesencumab	Inhibitor	99.34%	Phase 1
HY-P991329	ASP-1948	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (36)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-10799	EG00229 trifluoroacetate	Antagonist	98.03%	Unkown
HY-112151A	EG01377 dihydrochloride	Inhibitor	98.98%	Unkown
HY-133034	NRP1 antagonist 1	Antagonist	99.71%	Unkown
HY-112151	EG01377	Inhibitor	99.90%	Unkown
HY-P1663A	ATWLPPR Peptide TFA	Inhibitor	99.20%	Unkown
HY-P10787	tLyP-1 peptide	Inhibitor	98.05%	Unkown
HY-RS09579	NRP1 Human Pre-designed siRNA Set A		/	Unkown
HY-147762	NRP1 antagonist 2	Antagonist	99.05%	Unkown
HY-P10097	Flt2-11	Inhibitor	99.71%	Unkown
HY-182700	NRPa-308	Inhibitor	98.96%	Unkown
HY-P11286	A7RC		99.87%	Unkown
HY-P11647A	RPARPAR acetate	Ligand	99.47%	Unkown
HY-RS16529	Nrp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P3449	Dazdotuftide	Inhibitor	/	Unkown
HY-163062	Tubulin/NRP1-IN-1		/	Unkown
HY-179350	EG01449 Free acid	Inhibitor	/	Unkown
HY-179350A	EG01449	Inhibitor	/	Unkown
HY-18333	EG00229	Inhibitor	/	Unkown
HY-184566A	DPPE-PEG2000-iRGD		/	Unkown
HY-184567A	DSG-PEG2000-iRGD		/	Unkown
HY-184576	DOPE-PEG1000-iRGD		/	Unkown
HY-184576A	DOPE-PEG2000-iRGD		/	Unkown
HY-184576B	DOPE-PEG3400-iRGD		/	Unkown
HY-184576C	DOPE-PEG5000-iRGD		/	Unkown
HY-184577	DMG-PEG1000-iRGD		/	Unkown
HY-184577A	DMG-PEG2000-iRGD		/	Unkown
HY-184577B	DMG-PEG3400-iRGD		/	Unkown
HY-184577C	DMG-PEG5000-iRGD		/	Unkown
HY-NP223	PLGF-2 Protein, human		/	Unkown
HY-P10788	CK3 peptide	Inhibitor	/	Unkown
HY-P11647	RPARPAR	Ligand	/	Unkown
HY-RS09204	NELL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-128446	CAY10781	Inhibitor	98.04%	Unkown
HY-P3448S	Certepetide-13C6,15N2	Activator	/	Unkown
HY-P3448S1	Certepetide-13C2,15N	Activator	/	Unkown
HY-RS22960	Nrp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nrp1	NCBI	NCBI:8829