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Cat. No.: HY-18333

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EG00229

11 Cited Publications

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Based on 11 publication(s) in Google Scholar

EG00229 is an inhibitor for VEGF-A and NRP1 interaction with an IC₅₀ of 8 μM. EG00229 inhibits the migration of HUVECS and the phosphorylation of VEGFR2 in endothelial cells. EG00229 exhibits cytotoxicity in cancer cell A549.

For research use only. We do not sell to patients.

CAS No.: 1018927-63-3
Formula: C₁₇H₁₉N₇O₅S₃
Molecular Weight:497.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

EG00229 Chemical Structure

CAS No.: 1018927-63-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Publications (11)
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All VEGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	7 μM Compound: 2, EG00229	Displacement of [125I]VEGF-A from human NRP1 expressed in human A549 cells Displacement of [125I]VEGF-A from human NRP1 expressed in human A549 cells	[PMID: 20151671]
DU-145	IC₅₀	3 μM Compound: 2, EG00229	Displacement of biotinylated-VEGF-A125 from human NRP1 expressed in human DU145 cells Displacement of biotinylated-VEGF-A125 from human NRP1 expressed in human DU145 cells	[PMID: 20151671]
HEK293	IC₅₀	11.1 μM Compound: EG00229	Inhibition of recombinant human biotinylated VEGF-165A expressed in HEK293 cells binding to immobilized recombinant full length human FC-tagged NRP1 (chimera active) expressed in HEK293 cells using TMB as substrate incubated for 2 hrs followed by substrat Inhibition of recombinant human biotinylated VEGF-165A expressed in HEK293 cells binding to immobilized recombinant full length human FC-tagged NRP1 (chimera active) expressed in HEK293 cells using TMB as substrate incubated for 2 hrs followed by substrat	[PMID: 31744780]
HUVEC	IC₅₀	23 μM Compound: 2, EG00229	Displacement of biotinylated-VEGF-A125 from human NRP1 expressed in HUVEC Displacement of biotinylated-VEGF-A125 from human NRP1 expressed in HUVEC	[PMID: 20151671]

Chemical Information

CAS No. 1018927-63-3
Molecular Weight 497.57
Formula C₁₇H₁₉N₇O₅S₃
SMILES

N=C(N)NCCC[C@@H](C(O)=O)NC(C1=C(NS(=O)(C2=CC=CC3=NSN=C32)=O)C=CS1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (11)

All Cell Proliferation/Viability AssayWBCell Imaging/StainingRT-PCRIn Vivo Efficacy Study

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Journal Impact Factor

EBioMedicine

Neuropilin-1 aggravates liver cirrhosis by promoting angiogenesis via VEGFR2-dependent PI3K/Akt pathway in hepatic sinusoidal endothelial cells. [Abstract]

2019 May:43:525-536. PMID: 31060904

EG00229 purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2019 May:43:525-536. [Abstract]

EG00229 trifluoroacetate (NRP-1 inhibitor) (10-50 μM; once daily for 7 d) concentration-dependently increased the survival rate of fibrotic liver tissues from patients.

EG00229 purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2019 May:43:525-536. [Abstract]

EG00229 trifluoroacetate (NRP-1 inhibitor) (10-50 μM; once daily for 7 d) significantly decreased the mRNA levels of CD31, α-SMA, collagen1α I, and FN in fibrotic liver tissues from patients.
Proc Natl Acad Sci U S A

Targeting the ANGPTL4/NRP1/ABL1/RAD51 axis reverses cisplatin resistance by impairing DNA damage repair in head and neck cancer. [Abstract]

2026 Mar 31;123(13):e2510265123. PMID: 41886374

EG00229 purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2026 Mar 31;123(13):e2510265123. [Abstract]

NRP1 inhibitor EG00229 (10-100 μM) blocked ANGPTL4-induced RAD51 phosphorylation in Tyr315 and Tyr54 of NOKSI cells.

EG00229 purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2026 Mar 31;123(13):e2510265123. [Abstract]

EG00229 trifluoroacetate (NRPi) (10-50 µM; 48 h) led to an increase in the DDR in CAL27 cells.

EG00229 purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2026 Mar 31;123(13):e2510265123. [Abstract]

EG00229 trifluoroacetate (NRPi) (10 mg/kg; i.p.) sensitized CAL27 xenografts mice to a subtherapeutic dose of cisplatin (5 mg/kg) markedly reducing tumor volume respectively.
Acta Pharmacol Sin

Epigenetic regulation of NDGA and its synergistic inhibition with EZH2 inhibitors in prostate cancer via NRP1. [Abstract]

2026 Feb 19. PMID: 41714725
Mol Med

Epigenetic reprogramming drives endothelial dysfunction via neuropilin-1 in pulmonary hypertension. [Abstract]

2025 Dec 16;31(1):336. PMID: 41402732
Fluids Barriers CNS

SARS-CoV-2 causes dysfunction in human iPSC-derived brain microvascular endothelial cells potentially by modulating the Wnt signaling pathway. [Abstract]

2024 Apr 8;21(1):32. PMID: 38584257
Biochem Pharmacol

Pitavastatin overcomes multi-drug resistance in CRC and NSCLC by targeting the NRP1-ZFX axis. [Abstract]

2025 Jul 18:241:117183. PMID: 40684995
Biochem Pharmacol

Tuftsin ameliorates splenic inflammatory injury by promoting neuropilin-1 in severe acute pancreatitis. [Abstract]

2022 May;199:115030. PMID: 35381211
J Cancer

Effect of EG00229 on Radiation Resistance of Lung Adenocarcinoma Cells. [Abstract]

2021 Aug 24;12(20):6105-6117. PMID: 34539883
Bioorg Med Chem

Discovery of novel nonpeptide small-molecule NRP1 antagonists: Virtual screening, molecular simulation and structural modification. [Abstract]

2020 Jan 1;28(1):115183. PMID: 31744780
Cell Physiol Biochem

VEGF-A/Neuropilin 1 Pathway Confers Cancer Stemness via Activating Wnt/β-Catenin Axis in Breast Cancer Cells. [Abstract]

2017;44(3):1251-1262. PMID: 29179185

EG00229 purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2017;44(3):1251-1262. [Abstract]

The inhibitor of NRP-1 called EG00229 decreases sphere and clone formation in MDA-MB-231 cells.
bioRxiv

Neuropilin-1 is a co-receptor for Nerve Growth Factor-evoked pain. [Abstract]

2024 Oct 21:2023.12.06.570398. PMID: 38106002

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jarvis A, et al., Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem. 2010 Mar 11;53(5):2215-26. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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