EG00229

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EG00229 is an inhibitor for VEGF-A and NRP1 interaction with an IC₅₀ of 8 μM. EG00229 inhibits the migration of HUVECS and the phosphorylation of VEGFR2 in endothelial cells. EG00229 exhibits cytotoxicity in cancer cell A549.

For research use only. We do not sell to patients.

CAS No. : 1018927-63-3

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of EG00229:

EG00229 trifluoroacetate

Other Forms of EG00229:

EG00229 trifluoroacetate In-stock

11 Publications Citing Use of MCE EG00229

Cell Proliferation/Viability Assay

Cell Imaging/Staining

RT-PCR

In Vivo Efficacy Study

: EG00229 purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2026 Mar 31;123(13):e2510265123. [Abstract]; NRP1 inhibitor EG00229 (10-100 μM) blocked ANGPTL4-induced RAD51 phosphorylation in Tyr315 and Tyr54 of NOKSI cells.

: EG00229 purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2026 Mar 31;123(13):e2510265123. [Abstract]; EG00229 trifluoroacetate (NRPi) (10-50 µM; 48 h) led to an increase in the DDR in CAL27 cells.

: EG00229 purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2026 Mar 31;123(13):e2510265123. [Abstract]; EG00229 trifluoroacetate (NRPi) (10 mg/kg; i.p.) sensitized CAL27 xenografts mice to a subtherapeutic dose of cisplatin (5 mg/kg) markedly reducing tumor volume respectively.

: EG00229 purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2019 May:43:525-536. [Abstract]; EG00229 trifluoroacetate (NRP-1 inhibitor) (10-50 μM; once daily for 7 d) concentration-dependently increased the survival rate of fibrotic liver tissues from patients.

: EG00229 purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2019 May:43:525-536. [Abstract]; EG00229 trifluoroacetate (NRP-1 inhibitor) (10-50 μM; once daily for 7 d) significantly decreased the mRNA levels of CD31, α-SMA, collagen1α I, and FN in fibrotic liver tissues from patients.

: EG00229 purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2017;44(3):1251-1262. [Abstract]; The inhibitor of NRP-1 called EG00229 decreases sphere and clone formation in MDA-MB-231 cells.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	7 μM Compound: 2, EG00229	Displacement of [125I]VEGF-A from human NRP1 expressed in human A549 cells Displacement of [125I]VEGF-A from human NRP1 expressed in human A549 cells	[PMID: 20151671]
DU-145	IC₅₀	3 μM Compound: 2, EG00229	Displacement of biotinylated-VEGF-A125 from human NRP1 expressed in human DU145 cells Displacement of biotinylated-VEGF-A125 from human NRP1 expressed in human DU145 cells	[PMID: 20151671]
HEK293	IC₅₀	11.1 μM Compound: EG00229	Inhibition of recombinant human biotinylated VEGF-165A expressed in HEK293 cells binding to immobilized recombinant full length human FC-tagged NRP1 (chimera active) expressed in HEK293 cells using TMB as substrate incubated for 2 hrs followed by substrate addition by competitive ELISA Inhibition of recombinant human biotinylated VEGF-165A expressed in HEK293 cells binding to immobilized recombinant full length human FC-tagged NRP1 (chimera active) expressed in HEK293 cells using TMB as substrate incubated for 2 hrs followed by substrate addition by competitive ELISA	[PMID: 31744780]
HUVEC	IC₅₀	23 μM Compound: 2, EG00229	Displacement of biotinylated-VEGF-A125 from human NRP1 expressed in HUVEC Displacement of biotinylated-VEGF-A125 from human NRP1 expressed in HUVEC	[PMID: 20151671]

Molecular Weight

497.57

Formula

C₁₇H₁₉N₇O₅S₃

CAS No.

1018927-63-3

SMILES

N=C(N)NCCC[C@@H](C(O)=O)NC(C1=C(NS(=O)(C2=CC=CC3=NSN=C32)=O)C=CS1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jarvis A, et al., Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem. 2010 Mar 11;53(5):2215-26. [Content Brief]

EG00229 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EG002291018927-63-3EG 00229EG-00229VEGFRVascular endothelial growth factor receptorA549DU145HUVECslung cancerprostate carcinomaInhibitorinhibitorinhibit

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