1018927-63-3
1018927-63-3
Chemical Structure
EG00229
- CAS No.: 1018927-63-3
- Formula:C17H19N7O5S3
- Molecular Weight:497.57
IUPAC Name: (S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)thiophene-2-carboxamido)-5-guanidinopentanoic acid
InChIKey: ZWWMEDURALZMEV-NSHDSACASA-N
SMILES: N=C(N)NCCC[C@@H](C(O)=O)NC(C1=C(NS(=O)(C2=CC=CC3=NSN=C32)=O)C=CS1)=O
Biological Activity: EG00229 is an inhibitor for VEGF-A and NRP1 interaction with an IC50 of 8 μM. EG00229 inhibits the migration of HUVECS and the phosphorylation of VEGFR2 in endothelial cells. EG00229 exhibits cytotoxicity in cancer cell A549[1].
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EG00229 | EG00229 is an inhibitor for VEGF-A and NRP1 interaction with an IC50 of 8 μM. EG00229 inhibits the migration of HUVECS and the phosphorylation of VEGFR2 in endothelial cells. EG00229 exhibits cytotoxicity in cancer cell A549. | |||||||||||||||||||||
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References
Keywords
