UPK2 - uroplakin 2 Gene

Also Known as UP2; UPII

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7379

About UPK2

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,956,298-118,958,559 (from NCBI)

This gene has 2 transcripts (splice variants) and 100 orthologues. Biased expression in urinary bladder (RPKM 26.3) and fat (RPKM 1.3).

Summary

This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder Cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009]

UPK2 Products (1)

mRNA	Protein	Name
NM_006760.4	NP_006751.1	uroplakin-2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in epithelial cell differentiation	IDA IDA: Inferred from direct assay	10514386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UPK2 Protein Structure

Uroplakin_II

0
100
184 a.a.

Protein Preferred Names	Protein Names
uroplakin-2	uroplakin II

UPK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	UPK2	O00526	SMAGP	Homo sapiens	Q0VAQ4	Validated Y2H	32296183
Intra	UPK2	O00526	TTMP	Homo sapiens	Q5BVD1	Validated Y2H	32296183
Intra	UPK2	O00526	BSCL2	Homo sapiens	J3KQ12	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	BSCL2	Homo sapiens	J3KQ12	Y2H Array	32296183
Intra	UPK2	O00526	CLEC17A	Homo sapiens	Q6ZS10	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	CLEC17A	Homo sapiens	Q6ZS10	Y2H Array	32296183
Intra	UPK2	O00526	CLEC17A	Homo sapiens	Q6ZS10	Validated Y2H	32296183
Intra	UPK2	O00526	CLEC7A	Homo sapiens	Q9BXN2-6	Validated Y2H	32296183
Intra	UPK2	O00526	CLEC7A	Homo sapiens	Q9BXN2-6	Y2H Array	32296183
Intra	UPK2	O00526	CLEC7A	Homo sapiens	Q9BXN2-6	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	RNF170	Homo sapiens	Q96K19-5	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	RNF170	Homo sapiens	Q96K19-5	Validated Y2H	32296183
Intra	UPK2	O00526	RNF170	Homo sapiens	Q96K19-5	Y2H Array	32296183
Intra	UPK2	O00526	SLC22A23	Homo sapiens	A1A5C7-2	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	SLC22A23	Homo sapiens	A1A5C7-2	Y2H Array	32296183
Intra	UPK2	O00526	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	UPK2	O00526	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	UPK2	O00526	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	PLP1	Homo sapiens	P60201-2	Validated Y2H	32296183
Intra	UPK2	O00526	CD74	Homo sapiens	P04233-2	Validated Y2H	32296183
Intra	UPK2	O00526	CD74	Homo sapiens	P04233-2	Y2H Array	32296183
Intra	UPK2	O00526	CD74	Homo sapiens	P04233-2	Complementation	32296183
Intra	UPK2	O00526	CD74	Homo sapiens	P04233-2	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	TMPRSS2	Homo sapiens	O15393-2	Validated Y2H	32296183
Intra	UPK2	O00526	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	UPK2	O00526	ASGR2	Homo sapiens	P07307-3	Y2H Array	32296183
Intra	UPK2	O00526	ASGR2	Homo sapiens	P07307-3	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	ASGR2	Homo sapiens	P07307-3	Validated Y2H	32296183
Intra	UPK2	O00526	ITM2C	Homo sapiens	Q9NQX7-3	Validated Y2H	32296183
Intra	UPK2	O00526	ITM2C	Homo sapiens	Q9NQX7-3	Y2H Array	32296183
Intra	UPK2	O00526	HPN	Homo sapiens	P05981	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	HPN	Homo sapiens	P05981	Validated Y2H	32296183
Intra	UPK2	O00526	HPN	Homo sapiens	P05981	Y2H Array	32296183
Intra	UPK2	O00526	STOML3	Homo sapiens	Q8TAV4	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	STOML3	Homo sapiens	Q8TAV4	Validated Y2H	32296183
Intra	UPK2	O00526	STOML3	Homo sapiens	Q8TAV4	Y2H Array	32296183
Intra	UPK2	O00526	FCGR2A	Homo sapiens	P12318-2	Validated Y2H	32296183
Intra	UPK2	O00526	FCGR2A	Homo sapiens	P12318-2	Y2H Array	32296183
Intra	UPK2	O00526	FCGR2A	Homo sapiens	P12318-2	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	KIR3DL3	Homo sapiens	Q8N743	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	KIR3DL3	Homo sapiens	Q8N743	Validated Y2H	32296183
Intra	UPK2	O00526	KIR3DL3	Homo sapiens	Q8N743	Y2H Array	32296183
Intra	UPK2	O00526	BTNL9	Homo sapiens	Q6UXG8-3	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	BTNL9	Homo sapiens	Q6UXG8-3	Validated Y2H	32296183
Intra	UPK2	O00526	BTNL9	Homo sapiens	Q6UXG8-3	Y2H Array	32296183
Intra	UPK2	O00526	ADGRG3	Homo sapiens	Q86Y34	Validated Y2H	32296183
Intra	UPK2	O00526	ADGRG3	Homo sapiens	Q86Y34	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	ADGRG3	Homo sapiens	Q86Y34	Y2H Array	32296183
Intra	UPK2	O00526	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	UPK2	O00526	AMIGO1	Homo sapiens	Q86WK6	Validated Y2H	32296183
Intra	UPK2	O00526	ZNRF4	Homo sapiens	Q8WWF5	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	ZNRF4	Homo sapiens	Q8WWF5	Validated Y2H	32296183
Intra	UPK2	O00526	ZNRF4	Homo sapiens	Q8WWF5	Y2H Array	32296183
Intra	UPK2	O00526	ATP6AP2	Homo sapiens	O75787	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	ATP6AP2	Homo sapiens	O75787	Validated Y2H	32296183
Intra	UPK2	O00526	ATP6AP2	Homo sapiens	O75787	Y2H Array	32296183
Intra	UPK2	O00526	TMEM106C	Homo sapiens	Q9BVX2	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	TMEM106C	Homo sapiens	Q9BVX2	Validated Y2H	32296183
Intra	UPK2	O00526	TMEM106C	Homo sapiens	Q9BVX2	Y2H Array	32296183
Intra	UPK2	O00526	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	LIME1	Homo sapiens	Q9H400	Validated Y2H	32296183
Intra	UPK2	O00526	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	UPK2	O00526	FCGRT	Homo sapiens	P55899	Validated Y2H	32296183
Intra	UPK2	O00526	FCGRT	Homo sapiens	P55899	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	FCGRT	Homo sapiens	P55899	Y2H Array	32296183
Intra	UPK2	O00526	FCGR1A	Homo sapiens	P12314	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	FCGR1A	Homo sapiens	P12314	Y2H Array	32296183
Intra	UPK2	O00526	FCGR1A	Homo sapiens	P12314	Validated Y2H	32296183
Intra	UPK2	O00526	GPA33	Homo sapiens	Q99795	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	GPA33	Homo sapiens	Q99795	Y2H Array	32296183
Intra	UPK2	O00526	GPA33	Homo sapiens	Q99795	Validated Y2H	32296183
Intra	UPK2	O00526	TNFSF14	Homo sapiens	O43557	Validated Y2H	32296183
Intra	UPK2	O00526	TNFSF14	Homo sapiens	O43557	Y2H Array	32296183
Intra	UPK2	O00526	TNFSF14	Homo sapiens	O43557	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	TNFSF11	Homo sapiens	O14788	Validated Y2H	32296183
Intra	UPK2	O00526	TNFSF11	Homo sapiens	O14788	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	TNFSF11	Homo sapiens	O14788	Y2H Array	32296183
Intra	UPK2	O00526	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	UPK2	O00526	CLDN7	Homo sapiens	O95471	Validated Y2H	32296183
Intra	UPK2	O00526	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	25416956
Intra	UPK2	O00526	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	25416956
Intra	UPK2	O00526	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
Intra	UPK2	O00526	KIR2DL3	Homo sapiens	P43628	Validated Y2H	32296183
Intra	UPK2	O00526	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UPK2 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P71013	UPK2 Protein, Human (HEK293, His)	O00526 (D26-G155)	≥ 95%, as determined by reducing SDS-PAGE.

UPK2 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81514	Uroplakin II/UPII Antibody (YA1259)	IHC-P	Human
HY-P81514A	Uroplakin II/UPII Antibody (YA1259)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Bladder Carcinoma In Situ	Carcinoma In Situ Of Bladder Bladder Ca In Situ Flat Cis Of The Urinary Bladder Carcinoma In Situ Of Urinary Bladder
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Male Urethral Cancer	Male Urethral Malignant Neoplasm
Gastric Signet Ring Cell Adenocarcinoma	Signet Ring Cell Gastric Adenocarcinoma Signet Ring Cell Adenocarcinoma Of The Stomach
Interstitial Cystitis	Bladder Pain Syndrome Painful Bladder Syndrome Ulcerative Cystitis Ic/Bps Ic/Pbs Interstitial Cystitis/Bladder Pain Syndrome Interstitial Cystitis/Painful Bladder Syndrome Cystitis, Interstitial Chronic Interstitial Cystitis Pelvic Congestion Syndrome Trigonitis
Ovarian Cystic Teratoma
Fraser Syndrome 1	Fraser Syndrome Cryptophthalmos With Other Malformations Cryptophthalmos Syndrome FRASRS1 Cryptophthalmos-Syndactyly Syndrome Fraser-Francois Syndrome Cyclopism Meyer-Schwickerath'S Syndrome Ulrich-Feichtiger Syndrome Cryptophthalmos Syndactyly Syndrome Fraser'S Syndrome Meyer-Schwickerath Syndrome Ullrich-Feichtiger Syndrome
Urethral Stricture	Ankylurethria Urethral Stenosis Urethral Contracture Urethral Obstruction Meatal Stenosis Nos Constriction Of Urethra Contraction Of Urethra Stricture Of Urinary Meatus Urethral Obliteration Urethral Narrowing Pinpoint Meatus Pinhole Meatus Nos Urethral Occlusion
Cystitis Cystica
Acute Cystitis	Urinary Tract Infection Recurrent Urinary Tract Infection
Chronic Cystitis
Mature Teratoma Of The Ovary
Bladder Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Bladder Epidermoid Carcinoma Of The Urinary Bladder Carcinoma Squamous Cell Bladder
Prune Belly Syndrome	Eagle-Barrett Syndrome Abdominal Muscle Deficiency Syndrome PBS Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism Egbrs Eagle-Barret Syndrome Urethral Obstruction Sequence Obrinsky Syndrome Triad Syndrome Obrisnksy Syndrome Euos Early Urethral Obstruction Sequence Renal Dysplasia Or Hydronephrosis, Oligohydramnios And Subsequent Lung Hypoplasia Due To Urethral Obstruction Absence Of Abdominal Muscles With Urinary Tract Abnormality And Cryptorchidism Abdomen Muscle Deficiency Syndrome Abdomen Muscular Deficiency Syndrome Abdominal Muscular Deficiency Syndrome Abdominal Muscle Aplasia Syndrome
Vesicoureteral Reflux	Vesico-Ureteral Reflux
Hydronephrosis	Stricture Of Ureteropelvic Junction With Hydronephrosis Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Cakut	Renal Or Urinary Tract Malformation Congenital Anomalies Of Kidney And Urinary Tract Congenital Anomaly Of Kidney And Urinary Tract Congenital Anomalies Of The Kidney And Urinary Tract Kidney And Urinary Tract, Anomalies, Congenital Renal Hypodysplasia, Nonsyndromic, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS15487	UPK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19971	Upk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26474	Upk2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UPK2	VGNC	VGNC:36686
Felis catus	UPK2	VGNC	VGNC:66844
Rattus norvegicus	UPK2	RGD	RGD:1597393
Macaca mulatta	UPK2	VGNC	VGNC:107662
Canis familiaris	UPK2	VGNC	VGNC:48156
Mus musculus	UPK2	MGD	MGI:98913
Others	UPK2	NCBI