UPK2 Protein, Human (HEK293, His)
Based on 1 Customer Validation
UPK2 is a key component of the asymmetric unit membrane (AUM), a specialized biofilm made by terminally differentiated urothelial cells. Its presence suggests a potentially critical role in the complex regulation of AUM assembly. UPK2 Protein, Human (HEK293, His) is the recombinant human-derived UPK2 protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
UPK2 is a key component of the asymmetric unit membrane (AUM), a specialized biofilm made by terminally differentiated urothelial cells. Its presence suggests a potentially critical role in the complex regulation of AUM assembly. UPK2 Protein, Human (HEK293, His) is the recombinant human-derived UPK2 protein, expressed by HEK293 , with C-6*His labeled tag.
Background
The UPK2 protein serves as a crucial constituent of the asymmetric unit membrane (AUM), a specialized biomembrane intricately developed by fully differentiated urothelial cells. Its potential involvement in regulating AUM assembly underscores its significance in maintaining the structural integrity and specialized functions of urothelial cells. Through its interaction with uroplakin-1a (UPK1A), UPK2 forms part of a molecular network that likely contributes to the unique properties of the AUM. This association highlights the intricate interplay between UPK2 and UPK1A, shedding light on their cooperative roles in the intricate biology of terminally differentiated urothelial cells (By similarity).
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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Accession
O00526 (D26-G155)
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Molecular Construction
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N-term
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UPK2 (D26-G155)
Accession # O00526 -
6*His
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C-term
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Protein Length
Lumenal Domain (with Propeptide)
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Synonyms
UPK2; Uroplakin 2; UPII; UP2; Uroplakin II; Uroplakin-2; MGC138598
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AA Sequence
DFNISSLSGLLSPALTESLLVALPPCHLTGGNATLMVRRANDSKVVTSSFVVPPCRGRRELVSVVDSGAGFTVTRLSAYQVTNLVPGTKFYISYLVKKGTATESSREIPMSTLPRRNMESIGLGMARTGG
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Predicted Molecular Mass
14.8 kDa
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Molecular Weight
Approximately 27 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (235 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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