UPK2 - uroplakin 2 Gene

Also Known as UP2; UPII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7379

About UPK2

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,956,298-118,958,559 (from NCBI)

This gene has 2 transcripts (splice variants) and 100 orthologues. Biased expression in urinary bladder (RPKM 26.3) and fat (RPKM 1.3).

Summary

This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder Cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009]

UPK2 Products (1)

mRNA Protein Name
NM_006760.4 NP_006751.1 uroplakin-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in epithelial cell differentiation IDA
IDA: Inferred from direct assay
10514386 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UPK2 Protein Structure

Uroplakin_II

Uroplakin_II: Uroplakin II (1 - 184)

  • 0
  • 100
  • 184 a.a.
Protein Preferred Names Protein Names

uroplakin-2

  • uroplakin II

UPK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UPK2 O00526 SMAGP Homo sapiens Q0VAQ4
Validated Y2H
32296183
Intra
UPK2 O00526 TTMP Homo sapiens Q5BVD1
Validated Y2H
32296183
Intra
UPK2 O00526 BSCL2 Homo sapiens J3KQ12
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 BSCL2 Homo sapiens J3KQ12
Y2H Array
32296183
Intra
UPK2 O00526 CLEC17A Homo sapiens Q6ZS10
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 CLEC17A Homo sapiens Q6ZS10
Y2H Array
32296183
Intra
UPK2 O00526 CLEC17A Homo sapiens Q6ZS10
Validated Y2H
32296183
Intra
UPK2 O00526 CLEC7A Homo sapiens Q9BXN2-6
Validated Y2H
32296183
Intra
UPK2 O00526 CLEC7A Homo sapiens Q9BXN2-6
Y2H Array
32296183
Intra
UPK2 O00526 CLEC7A Homo sapiens Q9BXN2-6
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 RNF170 Homo sapiens Q96K19-5
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 RNF170 Homo sapiens Q96K19-5
Validated Y2H
32296183
Intra
UPK2 O00526 RNF170 Homo sapiens Q96K19-5
Y2H Array
32296183
Intra
UPK2 O00526 SLC22A23 Homo sapiens A1A5C7-2
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 SLC22A23 Homo sapiens A1A5C7-2
Y2H Array
32296183
Intra
UPK2 O00526 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra
UPK2 O00526 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
UPK2 O00526 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 PLP1 Homo sapiens P60201-2
Validated Y2H
32296183
Intra
UPK2 O00526 CD74 Homo sapiens P04233-2
Validated Y2H
32296183
Intra
UPK2 O00526 CD74 Homo sapiens P04233-2
Y2H Array
32296183
Intra
UPK2 O00526 CD74 Homo sapiens P04233-2
Complementation
32296183
Intra
UPK2 O00526 CD74 Homo sapiens P04233-2
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 TMPRSS2 Homo sapiens O15393-2
Validated Y2H
32296183
Intra
UPK2 O00526 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra
UPK2 O00526 ASGR2 Homo sapiens P07307-3
Y2H Array
32296183
Intra
UPK2 O00526 ASGR2 Homo sapiens P07307-3
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 ASGR2 Homo sapiens P07307-3
Validated Y2H
32296183
Intra
UPK2 O00526 ITM2C Homo sapiens Q9NQX7-3
Validated Y2H
32296183
Intra
UPK2 O00526 ITM2C Homo sapiens Q9NQX7-3
Y2H Array
32296183
Intra
UPK2 O00526 HPN Homo sapiens P05981
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 HPN Homo sapiens P05981
Validated Y2H
32296183
Intra
UPK2 O00526 HPN Homo sapiens P05981
Y2H Array
32296183
Intra
UPK2 O00526 STOML3 Homo sapiens Q8TAV4
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 STOML3 Homo sapiens Q8TAV4
Validated Y2H
32296183
Intra
UPK2 O00526 STOML3 Homo sapiens Q8TAV4
Y2H Array
32296183
Intra
UPK2 O00526 FCGR2A Homo sapiens P12318-2
Validated Y2H
32296183
Intra
UPK2 O00526 FCGR2A Homo sapiens P12318-2
Y2H Array
32296183
Intra
UPK2 O00526 FCGR2A Homo sapiens P12318-2
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 KIR3DL3 Homo sapiens Q8N743
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 KIR3DL3 Homo sapiens Q8N743
Validated Y2H
32296183
Intra
UPK2 O00526 KIR3DL3 Homo sapiens Q8N743
Y2H Array
32296183
Intra
UPK2 O00526 BTNL9 Homo sapiens Q6UXG8-3
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 BTNL9 Homo sapiens Q6UXG8-3
Validated Y2H
32296183
Intra
UPK2 O00526 BTNL9 Homo sapiens Q6UXG8-3
Y2H Array
32296183
Intra
UPK2 O00526 ADGRG3 Homo sapiens Q86Y34
Validated Y2H
32296183
Intra
UPK2 O00526 ADGRG3 Homo sapiens Q86Y34
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 ADGRG3 Homo sapiens Q86Y34
Y2H Array
32296183
Intra
UPK2 O00526 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
Intra
UPK2 O00526 AMIGO1 Homo sapiens Q86WK6
Validated Y2H
32296183
Intra
UPK2 O00526 ZNRF4 Homo sapiens Q8WWF5
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 ZNRF4 Homo sapiens Q8WWF5
Validated Y2H
32296183
Intra
UPK2 O00526 ZNRF4 Homo sapiens Q8WWF5
Y2H Array
32296183
Intra
UPK2 O00526 ATP6AP2 Homo sapiens O75787
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 ATP6AP2 Homo sapiens O75787
Validated Y2H
32296183
Intra
UPK2 O00526 ATP6AP2 Homo sapiens O75787
Y2H Array
32296183
Intra
UPK2 O00526 TMEM106C Homo sapiens Q9BVX2
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 TMEM106C Homo sapiens Q9BVX2
Validated Y2H
32296183
Intra
UPK2 O00526 TMEM106C Homo sapiens Q9BVX2
Y2H Array
32296183
Intra
UPK2 O00526 LIME1 Homo sapiens Q9H400
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 LIME1 Homo sapiens Q9H400
Validated Y2H
32296183
Intra
UPK2 O00526 LIME1 Homo sapiens Q9H400
Y2H Array
32296183
Intra
UPK2 O00526 FCGRT Homo sapiens P55899
Validated Y2H
32296183
Intra
UPK2 O00526 FCGRT Homo sapiens P55899
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 FCGRT Homo sapiens P55899
Y2H Array
32296183
Intra
UPK2 O00526 FCGR1A Homo sapiens P12314
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 FCGR1A Homo sapiens P12314
Y2H Array
32296183
Intra
UPK2 O00526 FCGR1A Homo sapiens P12314
Validated Y2H
32296183
Intra
UPK2 O00526 GPA33 Homo sapiens Q99795
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 GPA33 Homo sapiens Q99795
Y2H Array
32296183
Intra
UPK2 O00526 GPA33 Homo sapiens Q99795
Validated Y2H
32296183
Intra
UPK2 O00526 TNFSF14 Homo sapiens O43557
Validated Y2H
32296183
Intra
UPK2 O00526 TNFSF14 Homo sapiens O43557
Y2H Array
32296183
Intra
UPK2 O00526 TNFSF14 Homo sapiens O43557
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 TNFSF11 Homo sapiens O14788
Validated Y2H
32296183
Intra
UPK2 O00526 TNFSF11 Homo sapiens O14788
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 TNFSF11 Homo sapiens O14788
Y2H Array
32296183
Intra
UPK2 O00526 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
UPK2 O00526 CLDN7 Homo sapiens O95471
Validated Y2H
32296183
Intra
UPK2 O00526 KASH5 Homo sapiens Q8N6L0
Validated Y2H
25416956
Intra
UPK2 O00526 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
25416956
Intra
UPK2 O00526 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra
UPK2 O00526 KIR2DL3 Homo sapiens P43628
Validated Y2H
32296183
Intra
UPK2 O00526 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UPK2 Proteins

Cat. No. Product Name Accession Purity
HY-P71013 UPK2 Protein, Human (HEK293, His) O00526 (D26-G155) ≥ 95%, as determined by reducing SDS-PAGE.

UPK2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81514 Uroplakin II/UPII Antibody (YA1259) IHC-P Human
HY-P81514A Uroplakin II/UPII Antibody (YA1259)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Transitional Cell Carcinoma

  • Transitional Cell Neoplasm

  • Carcinoma, Transitional Cell

  • Transitional Carcinoma

  • Transitional Cell Tumor

  • Urothelial Cell Carcinoma

  • Carcinoma Transitional Cell

  • Transitional Cell Carcinoma Of Bladder
Bladder Carcinoma In Situ

  • Carcinoma In Situ Of Bladder

  • Bladder Ca In Situ

  • Flat Cis Of The Urinary Bladder

  • Carcinoma In Situ Of Urinary Bladder
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Male Urethral Cancer

  • Male Urethral Malignant Neoplasm
Gastric Signet Ring Cell Adenocarcinoma

  • Signet Ring Cell Gastric Adenocarcinoma

  • Signet Ring Cell Adenocarcinoma Of The Stomach
Interstitial Cystitis

  • Bladder Pain Syndrome

  • Painful Bladder Syndrome

  • Ulcerative Cystitis

  • Ic/Bps

  • Ic/Pbs

  • Interstitial Cystitis/Bladder Pain Syndrome

  • Interstitial Cystitis/Painful Bladder Syndrome

  • Cystitis, Interstitial

  • Chronic Interstitial Cystitis

  • Pelvic Congestion Syndrome

  • Trigonitis
Ovarian Cystic Teratoma
Fraser Syndrome 1

  • Fraser Syndrome

  • Cryptophthalmos With Other Malformations

  • Cryptophthalmos Syndrome

  • FRASRS1

  • Cryptophthalmos-Syndactyly Syndrome

  • Fraser-Francois Syndrome

  • Cyclopism

  • Meyer-Schwickerath'S Syndrome

  • Ulrich-Feichtiger Syndrome

  • Cryptophthalmos Syndactyly Syndrome

  • Fraser'S Syndrome

  • Meyer-Schwickerath Syndrome

  • Ullrich-Feichtiger Syndrome
Urethral Stricture

  • Ankylurethria

  • Urethral Stenosis

  • Urethral Contracture

  • Urethral Obstruction

  • Meatal Stenosis Nos

  • Constriction Of Urethra

  • Contraction Of Urethra

  • Stricture Of Urinary Meatus

  • Urethral Obliteration

  • Urethral Narrowing

  • Pinpoint Meatus

  • Pinhole Meatus Nos

  • Urethral Occlusion
Cystitis Cystica
Acute Cystitis

  • Urinary Tract Infection

  • Recurrent Urinary Tract Infection
Chronic Cystitis
Mature Teratoma Of The Ovary
Bladder Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Bladder

  • Epidermoid Carcinoma Of The Urinary Bladder

  • Carcinoma Squamous Cell Bladder
Prune Belly Syndrome

  • Eagle-Barrett Syndrome

  • Abdominal Muscle Deficiency Syndrome

  • PBS

  • Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism

  • Egbrs

  • Eagle-Barret Syndrome

  • Urethral Obstruction Sequence

  • Obrinsky Syndrome

  • Triad Syndrome

  • Obrisnksy Syndrome

  • Euos

  • Early Urethral Obstruction Sequence

  • Renal Dysplasia Or Hydronephrosis, Oligohydramnios And Subsequent Lung Hypoplasia Due To Urethral Obstruction

  • Absence Of Abdominal Muscles With Urinary Tract Abnormality And Cryptorchidism

  • Abdomen Muscle Deficiency Syndrome

  • Abdomen Muscular Deficiency Syndrome

  • Abdominal Muscular Deficiency Syndrome

  • Abdominal Muscle Aplasia Syndrome
Vesicoureteral Reflux

  • Vesico-Ureteral Reflux
Hydronephrosis

  • Stricture Of Ureteropelvic Junction With Hydronephrosis

  • Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Cakut

  • Renal Or Urinary Tract Malformation

  • Congenital Anomalies Of Kidney And Urinary Tract

  • Congenital Anomaly Of Kidney And Urinary Tract

  • Congenital Anomalies Of The Kidney And Urinary Tract

  • Kidney And Urinary Tract, Anomalies, Congenital

  • Renal Hypodysplasia, Nonsyndromic, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15487 UPK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19971 Upk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26474 Upk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus UPK2 VGNC VGNC:36686
Felis catus UPK2 VGNC VGNC:66844
Rattus norvegicus UPK2 RGD RGD:1597393
Macaca mulatta UPK2 VGNC VGNC:107662
Canis familiaris UPK2 VGNC VGNC:48156
Mus musculus UPK2 MGD MGI:98913
Others UPK2 NCBI