TASP0376377
TASP0376377 is a potent and selective CRTH2 antagonist (IC50: 13 nM). TASP0376377 has binding affinity for CRTH2 (IC50: 19 nM).
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- CAS No.: 1233246-60-0
- Formule: C25H16Cl2N2O4
- Masse moléculaire:479.31
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
19 nM
Compound: 15-20, TASP0376377
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Displacement of [3H]PGD2 from human CRTH2 transfected in CHO cells by liquid scintillation counting analysis
Displacement of [3H]PGD2 from human CRTH2 transfected in CHO cells by liquid scintillation counting analysis
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[PMID: 24216094] |
| CHO | IC50 |
19 nM
Compound: 6m, TASP0376377
|
Displacement of 3H-PGD2 from human CRTH2 receptor expressed in CHO cells
Displacement of 3H-PGD2 from human CRTH2 receptor expressed in CHO cells
|
[PMID: 22469703] |
Chemical Information
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CAS No. 1233246-60-0
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Masse moléculaire 479.31
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Formule C25H16Cl2N2O4
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SMILES
O=C(NC1=CC=C(C=C1)C(C2=NC=C(C3=C2C=CC=C3)CC(O)=O)=O)C4=CC=C(C(Cl)=C4)Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)