2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Nuclear Factor of activated T Cells (NFAT) NF-κB Reactive Oxygen Species
  4. CPS-11

CPS-11  (Synonyms: N-(Hydroxymethyl)thalidomide)

Cat. No.: HY-117987
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CPS-11 (N-(Hydroxymethyl)thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB, activates NFAT, and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines.

For research use only. We do not sell to patients.

CPS-11 Chemical Structure

CPS-11 Chemical Structure

CAS No. : 145945-21-7

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CPS-11 Related Antibodies

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Description

CPS-11 (N-(Hydroxymethyl)thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB, activates NFAT, and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines[1][2][3].

In Vitro

CPS-11 abrogates ability of bone marrow stromal cells (BMSCs) to induce proliferation of MM cells, confirming its ability to target tumor cells in the bone marrow microenvironment[1].
CPS-11 (0-200 μM, 0 or 4 h) shows virtually no effect on activation of p38 and only slight, transient activation of ATF2 and HSP27[2].
CPS-11 (0-100 μM, 24 or 48 h) was no toxic to H157 cells, WT MEFs or the p38α-/- MEFs at doses as high as 100 μM[2].
CPS-11 (50 μM, 24 or 48 h) does not induce apoptosis in H157 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CPS-11 Related Antibodies

Western Blot Analysis[2]

Cell Line: H157 cells, PC3 cells, HUVEC cells
Concentration: 0, 1, 5, 10, 20, 50, 100 and 200 μM
Incubation Time: 0, 15 min, 30 min, 1 h, 2 h, and 4 h
Result: Showed virtually no effect on activation of p38 and only slight, transient activation of ATF2 and HSP27. Increased Akt phosphorylation within 15 minutes, and decreased Akt phosphorylation from 15 minutes to 4 hours.

Cell Cytotoxicity Assay[2]

Cell Line: H157 cells, wild-type (WT) mouse embryonic fibroblasts (MEF) and p38α-/- MEF
Concentration: 0, 20, 50, and 100 μM
Incubation Time: 24 or 48 hours
Result: Showed no toxic to H157 cells at doses as high as 100 μM and an incubation time of 48 hours. had no toxic effect on either the WT MEFs or the p38α-/- MEFs at doses as high as 100 μM.

Apoptosis Analysis[2]

Cell Line: H157 cells
Concentration: 50 μM
Incubation Time: 24 or 48 hours
Result: Did not induce apoptosis in H157 cells at either time point.
Molecular Weight

288.26

Formula

C14H12N2O5
CAS No.
SMILES

O=C1N(C(C2=C1C=CC=C2)=O)C(C(N3CO)=O)CCC3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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CPS-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPS-11145945-21-7N-(Hydroxymethyl)thalidomideCPS11CPS 11Nuclear Factor of activated T Cells (NFAT)NF-κBReactive Oxygen SpeciesNuclear factor-κBNuclear factor-kappaBH157 cellsPC3 cellsH1703 cellsmouse embryonic fibroblastsMEFp38bone marrow stromal cellsBMSCATF2HSP27Multiple MyelomaMMProstate cancerThalidomideInhibitorinhibitorinhibit

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