2-Naphthol
Based on 1 publication(s) in Google Scholar
2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).
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- Reinheit: 99.91%
- CAS. Nr.: 135-19-3
- Formel: C10H8O
- Molecular Weight:144.17
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Speicherung:
RT, stored under nitrogen.
In solvent -80°C, 1 year , -20°C, 6 months
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Publications Citing Use of MedChemExpress (MCE) 2-Naphthol
MoreAlle Endogenous Metabolite Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BXPC-3 | ED50 |
21 μM
Compound: 2-Naphthol
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Cytotoxicity against human BXPC-3 cells assessed as cell index incubated for 72 hrs by xCELLigence real time cell analyser method
Cytotoxicity against human BXPC-3 cells assessed as cell index incubated for 72 hrs by xCELLigence real time cell analyser method
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[PMID: 38903945] |
| K562 | IC50 |
>100 μM
Compound: 2-Naphthol
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Cytotoxicity in human K562 cells assessed as reduction in cell viability incubated for 72 hrs by cell-QB reagent based assay
Cytotoxicity in human K562 cells assessed as reduction in cell viability incubated for 72 hrs by cell-QB reagent based assay
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[PMID: 30199251] |
2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2). 2-Naphthol (10, 25, 50 and 100 μM) causes no cytotoxic effect and the inhibition of peripheral-blood mononuclear cells proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 135-19-3
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Appearance Solid
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Molecular Weight 144.17
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Formel C10H8O
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Color Off-white to light brown
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SMILES
OC1=CC=C2C=CC=CC2=C1
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
RT, stored under nitrogen
In solvent -80°C 1 year -20°C 6 months
Publications (1)
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Journal Impact Factor
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Most Recent
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Fish Shellfish Immunol
Emodin enhances host antiviral immunity against Micropterus salmoides rhabdovirus by activating RLR signaling in largemouth bass. [Abstract]2025 Aug 6:166:110633. PMID: 40769268
Lösungsmittel & Löslichkeit
DMSO : ≥ 100 mg/mL (693.63 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 1 mg/mL (6.94 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (17.34 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (17.34 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (758 KB)
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- Portuguese - PT (758 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 6.9363 mL | 34.6813 mL | 69.3626 mL | 173.4064 mL |
| 5 mM | 1.3873 mL | 6.9363 mL | 13.8725 mL | 34.6813 mL | |
| DMSO | 10 mM | 0.6936 mL | 3.4681 mL | 6.9363 mL | 17.3406 mL |
| 15 mM | 0.4624 mL | 2.3121 mL | 4.6242 mL | 11.5604 mL | |
| 20 mM | 0.3468 mL | 1.7341 mL | 3.4681 mL | 8.6703 mL | |
| 25 mM | 0.2775 mL | 1.3873 mL | 2.7745 mL | 6.9363 mL | |
| 30 mM | 0.2312 mL | 1.1560 mL | 2.3121 mL | 5.7802 mL | |
| 40 mM | 0.1734 mL | 0.8670 mL | 1.7341 mL | 4.3352 mL | |
| 50 mM | 0.1387 mL | 0.6936 mL | 1.3873 mL | 3.4681 mL | |
| 60 mM | 0.1156 mL | 0.5780 mL | 1.1560 mL | 2.8901 mL | |
| 80 mM | 0.0867 mL | 0.4335 mL | 0.8670 mL | 2.1676 mL | |
| 100 mM | 0.0694 mL | 0.3468 mL | 0.6936 mL | 1.7341 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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