CHK1-IN-2
CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC50 of 6 nM.
For research use only. We do not sell to patients.
- CAS No.: 912367-45-4
- Formula: C20H22N4OS
- Molecular Weight:366.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Chk1 6 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | GI50 |
306 nM
Compound: 44
|
Antiproliferative activity against human MDA-MB-231 cells
Antiproliferative activity against human MDA-MB-231 cells
|
[PMID: 29301085] |
| NCI-H460 | GI50 |
2453 nM
Compound: 44
|
Antiproliferative activity against human H460 cells harboring dominant negative p53 construct
Antiproliferative activity against human H460 cells harboring dominant negative p53 construct
|
[PMID: 29301085] |
| SW-620 | GI50 |
725 nM
Compound: 44
|
Antiproliferative activity against human SW620 cells
Antiproliferative activity against human SW620 cells
|
[PMID: 29301085] |
CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC50 of 6 nM, which is a potential cancer therapeutic that can be utilized for enhancing the efficacy of DNA damaging agents[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 912367-45-4
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Molecular Weight 366.48
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Formula C20H22N4OS
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SMILES
O=C(N)C1=C(SC(C2=CC=CC=C2)=C3)C3=C(N[C@@H]4[C@@H](C)NCCC4)N=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)