2. Immunology/Inflammation
  3. Interleukin Related
  4. Dendronobiloside D

Dendronobiloside D is a sesquiterpene glycoside that can be isolated from Dendrobium officinale. Dendronobiloside D is an immunosuppressant that promotes the differentiation of CD4+ T cells into Treg cells.

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Dendronobiloside D

Dendronobiloside D Chemical Structure

CAS No. : 526222-27-5

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Dendronobiloside D Related Antibodies

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Description

Dendronobiloside D is a sesquiterpene glycoside that can be isolated from Dendrobium officinale. Dendronobiloside D is an immunosuppressant that promotes the differentiation of CD4+ T cells into Treg cells[1][2].

IC50 & Target[1]

IL-12

 

In Vitro

Dendronobiloside D downregulated the expression of IFNG, IL-6, and IL-12 mRNA in primary T cells, and upregulated the expression of TGFB mRNA[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dendronobiloside D Related Antibodies
Parmacokinetics
Species Dose Route AUC0-t AUC0-∞ Cmax Tmax T1/2 CLz/F Vz/F
Rat[1] 6.25 g/kg p.o. 14.38 ± 1.72 μg/L·h 17.29 ± 1.99 μM/L·h 2.28 ± 0.18 μg/L 1.50 ± 0.55 h 5.72 ± 2.91 h 6.11 ± 0.74 L/h/kg 26.36 ± 32.39 L/kg
In Vivo

Dendronobiloside D (6.25 g/kg; p.o.; single dose), administered as part of a Dendrobium nobile aqueous extract to rats, shows low plasma exposure with a Cmax of 2.28 ± 0.18 μg/L, rapid absorption with a Tmax of 1.50 h, and a terminal elimination half-life of 5.72 h[2].
Dendronobiloside D (6.25 g/kg; i.g.; single dose), administered as part of a Dendrobium nobile aqueous extract to rats, distributes widely to visceral and gastrointestinal tissues (excluding the brain) with highest concentrations in the small intestine, stomach, and large intestine[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (male, 6-8 weeks old, 220±20 g)[1]
Dosage: 6.25 g/kg (equivalent raw herb dose, as component of Dendrobium nobile aqueous extract)
Administration: i.g.; single dose
Result: Was detectable in all collected tissues except the brain.
Reached distribution concentration peaks generally within 2 hours post-administration.
Showed declining distribution concentrations between 2 and 6 hours post-administration.
Had tissue distribution levels ranked as: small intestine > stomach > large intestine > pancreas > lungs > kidneys > liver > heart > thymus > spleen > brain (undetectable).
Exhibited concentrations in the gastrointestinal tract (small intestine, stomach, large intestine) approximately 30 times higher than in heart, thymus, and spleen.
Molecular Weight

560.63

Formula

C27H44O12
CAS No.
SMILES

OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OCC2=C3[C@](C=C(CC3)C)([H])[C@@H](CC2)C(C)CO[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dendronobiloside D Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dendronobiloside D526222-27-5Interleukin RelatedILratsplasmasmall intestineDendrobium nobilebrainheartlungsliverkidneysspleenInhibitorinhibitorinhibit

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