1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Dibenamine hydrochloride

Dibenamine hydrochloride (Synonyms: N-​(2-​Chloroethyl)​dibenzylamine hydrochloride)

Cat. No.: HY-128380
Handling Instructions

Dibenamine hydrochloride is a competitive and irreversible adrenergic blocking agent and is known to modify the pharmacological effects of epinephrine. Dibenamine hydrochloride cause a significant increase in the rate of destruction of I-epinephrine in the mouse.

For research use only. We do not sell to patients.

Dibenamine hydrochloride Chemical Structure

Dibenamine hydrochloride Chemical Structure

CAS No. : 55-43-6

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Description

Dibenamine hydrochloride is a competitive and irreversible adrenergic blocking agent and is known to modify the pharmacological effects of epinephrine. Dibenamine hydrochloride cause a significant increase in the rate of destruction of I-epinephrine in the mouse[1][2].

IC50 & Target

IC50: Adrenergic receptor[1]

In Vitro

Dibenamine (100 nM-10 μM) attenuates the degree of cocaine-induced increase in sensitivity to acetylcholine without any effect on acetylcholine-contraction in isolated vas deferens of guinea pig. Additionally, the degree of dibenamine-induced inhibition dependent on the concentration of dibenamine and inversely related to the concentration of cocaine[3].

In Vivo

Dibenamine hydrochloride (subcutaneous injection; 25 mg/kg; 48 and 24 hr before the administration of CCl4) decreases the CHCl3, levels at 2 and 6 hr by 30-50 percent, but did not appreciably affect the half-life of CHCl3, in the liver.Pretreatment with Dibenamine apparently slows the conversion of Ccl4 to CHCL3[1].

Molecular Weight

296.23

Formula

C₁₆H₁₉Cl₂N

CAS No.

55-43-6

SMILES

ClCCN(CC1=CC=CC=C1)CC2=CC=CC=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

DibenamineN-​(2-​Chloroethyl)​dibenzylamineAdrenergic ReceptorBeta ReceptorAcetylcholineadrenergicepinephrinehepatotoxicityInhibitorinhibitorinhibit

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Dibenamine hydrochloride
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