1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Dibenamine hydrochloride

Dibenamine hydrochloride (Synonyms: N-​(2-​Chloroethyl)​dibenzylamine hydrochloride)

Cat. No.: HY-128380 Purity: ≥98.0%
Handling Instructions

Dibenamine hydrochloride is a competitive and irreversible adrenergic blocking agent and is known to modify the pharmacological effects of epinephrine. Dibenamine hydrochloride cause a significant increase in the rate of destruction of I-epinephrine in the mouse.

For research use only. We do not sell to patients.

Dibenamine hydrochloride Chemical Structure

Dibenamine hydrochloride Chemical Structure

CAS No. : 55-43-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
250 mg USD 50 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Dibenamine hydrochloride is a competitive and irreversible adrenergic blocking agent and is known to modify the pharmacological effects of epinephrine. Dibenamine hydrochloride cause a significant increase in the rate of destruction of I-epinephrine in the mouse[1][2].

IC50 & Target

IC50: Adrenergic receptor[1]

In Vitro

Dibenamine (100 nM-10 μM) attenuates the degree of cocaine-induced increase in sensitivity to acetylcholine without any effect on acetylcholine-contraction in isolated vas deferens of guinea pig. Additionally, the degree of dibenamine-induced inhibition dependent on the concentration of dibenamine and inversely related to the concentration of cocaine[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dibenamine hydrochloride (subcutaneous injection; 25 mg/kg; 48 and 24 hr before the administration of CCl4) decreases the CHCl3, levels at 2 and 6 hr by 30-50 percent, but did not appreciably affect the half-life of CHCl3, in the liver.Pretreatment with Dibenamine apparently slows the conversion of Ccl4 to CHCL3[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

296.23

Formula

C₁₆H₁₉Cl₂N

CAS No.
SMILES

ClCCN(CC1=CC=CC=C1)CC2=CC=CC=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (421.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3758 mL 16.8788 mL 33.7575 mL
5 mM 0.6752 mL 3.3758 mL 6.7515 mL
10 mM 0.3376 mL 1.6879 mL 3.3758 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.02 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.02 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.02 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

DibenamineN-​(2-​Chloroethyl)​dibenzylamineAdrenergic ReceptorBeta ReceptorAcetylcholineadrenergicepinephrinehepatotoxicityInhibitorinhibitorinhibit

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Product Name:
Dibenamine hydrochloride
Cat. No.:
HY-128380
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