2. GPCR/G Protein
    Neuronal Signaling
  3. Adrenergic Receptor
  4. Dibenamine hydrochloride

Dibenamine hydrochloride  (Synonyms: N-​(2-​Chloroethyl)​dibenzylamine hydrochloride)

Cat. No.: HY-128380 Purity: ≥98.0%
COA Handling Instructions

Dibenamine hydrochloride is a competitive and irreversible adrenergic blocking agent and is known to modify the pharmacological effects of epinephrine. Dibenamine hydrochloride cause a significant increase in the rate of destruction of I-epinephrine in the mouse.

For research use only. We do not sell to patients.

Dibenamine hydrochloride Chemical Structure

Dibenamine hydrochloride Chemical Structure

CAS No. : 55-43-6

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
250 mg USD 50 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Dibenamine hydrochloride is a competitive and irreversible adrenergic blocking agent and is known to modify the pharmacological effects of epinephrine. Dibenamine hydrochloride cause a significant increase in the rate of destruction of I-epinephrine in the mouse[1][2].

IC50 & Target

IC50: Adrenergic receptor[1]
In Vitro

Dibenamine (100 nM-10 μM) attenuates the degree of cocaine-induced increase in sensitivity to acetylcholine without any effect on acetylcholine-contraction in isolated vas deferens of guinea pig. Additionally, the degree of dibenamine-induced inhibition dependent on the concentration of dibenamine and inversely related to the concentration of cocaine[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Dibenamine hydrochloride (subcutaneous injection; 25 mg/kg; 48 and 24 hr before the administration of CCl4) decreases the CHCl3, levels at 2 and 6 hr by 30-50 percent, but did not appreciably affect the half-life of CHCl3, in the liver.Pretreatment with Dibenamine apparently slows the conversion of Ccl4 to CHCL3[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

296.23

Appearance

Solid

Formula

C16H19Cl2N
CAS No.
SMILES

ClCCN(CC1=CC=CC=C1)CC2=CC=CC=C2.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (421.97 mM; Need ultrasonic)

H2O : 33.33 mg/mL (112.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3758 mL 16.8788 mL 33.7575 mL
5 mM 0.6752 mL 3.3758 mL 6.7515 mL
10 mM 0.3376 mL 1.6879 mL 3.3758 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 9.09 mg/mL (30.69 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.02 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.02 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.02 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Dibenamine55-43-6N-​(2-​Chloroethyl)​dibenzylamineAdrenergic ReceptorBeta ReceptorAcetylcholineadrenergicepinephrinehepatotoxicityInhibitorinhibitorinhibit

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