(E)-C-HDMAPP ammonium
(E)-C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E)-HDMAPP. (E)-C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC50=0.91 nM for TNF-α release).
For research use only. We do not sell to patients.
- CAS No.: 933030-60-5
- Formula: C6H23N3O7P2
- Molecular Weight:311.21
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TNFRSF1A |
(E)-C-HDMAPP (compound 5E) (2 μM) increases the release of TNF-α in primary polyclonal human Vγ9Vδ2 T-cell with stimulating bioactivity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nonhuman Primate Model in Cynomolgus[1]
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Dosage:0.02 mg/kg, 0.1 mg/kg, 0.5 mg/kg, 2.5 mg/kg, 5 mg/kg, and 10 mg/kg
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Administration:Intravenous injection; once with daily s.c. low doses IL-2 to sustain γδ-T-cell proliferation, for 15 days
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Result:Significantly increased γδ-cells in vivo at 0.02 mg/kg. Reached maximal effect at 5 mg/kg and 10 mg/kg.
Chemical Information
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CAS No. 933030-60-5
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Molecular Weight 311.21
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Formula C6H23N3O7P2
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SMILES
OC/C(C)=C/CCP(OP(O)(O)=O)(O)=O.N.N.N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(E)-C-HDMAPP ammonium Related Classifications
HY-134950 Related Classifications
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