1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. EGFR-IN-7

EGFR-IN-7 

Cat. No.: HY-128862
Handling Instructions

EGFR-IN-7 (compound 34) is a selective and potent EGFR kinase inhibitor extracted from patent WO2019015655A1, has IC50s of 7.92 nM and 0.218 nM for EGFR (WT) and EGFR (mutant C797S/T790M/L858R) respectively, and shows anti-tumor activity.

For research use only. We do not sell to patients.

EGFR-IN-7 Chemical Structure

EGFR-IN-7 Chemical Structure

CAS No. : 2267329-76-8

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Description

EGFR-IN-7 (compound 34) is a selective and potent EGFR kinase inhibitor extracted from patent WO2019015655A1, has IC50s of 7.92 nM and 0.218 nM for EGFR (WT) and EGFR (mutant C797S/T790M/L858R) respectively, and shows anti-tumor activity[1].

IC50 & Target

EGFR (WT)

7.92 nM (IC50)

EGFR (C797S/T790M/L858R)

0.218 nM (IC50)

Molecular Weight

694.60

Formula

C₃₂H₄₁BrN₉O₂P

CAS No.

2267329-76-8

SMILES

CN1CCN(C2CCN(C3=C(C)C=C(NC4=NC=C(Br)C(NC5=CC=C6N=CC=NC6=C5P(C)(C)=O)=N4)C(OC)=C3)CC2)CC1

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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EGFR-IN-7
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HY-128862
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